Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - School of Medicine, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Department of Neurology, Washington University in St. Louis - School of Medicine, Banner Health, Washington University in St. Louis - School of Medicine, Washington University in St. Louis - School of Medicine, Washington University in St. Louis - School of Medicine, Washington University in St. Louis - School of Medicine, Washington University in St. Louis - Department of Radiology, Washington University in St. Louis - Department of Radiology, Washington University in St. Louis - School of Medicine, F Hoffmann-La Roche Ltd, F Hoffmann-La Roche Ltd, F Hoffmann-La Roche Ltd, F Hoffmann-La Roche Ltd, F Hoffmann-La Roche Ltd, F Hoffmann-La Roche Ltd, F Hoffmann-La Roche Ltd, F Hoffmann-La Roche Ltd, F Hoffmann-La Roche Ltd, F Hoffmann-La Roche Ltd, University of Zurich - Institute for Regenerative Medicine (IREM), Washington University in St. Louis - School of Medicine, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Department of Pathology and Immunology, Washington University in St. Louis - Knight Alzheimer Disease Research Center, National Institutes of Health - Neuromuscular Diseases Research Section, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Icahn School of Medicine at Mount Sinai - Department of Genetics and Genomic Sciences, Washington University in St. Louis - Department of Radiology, Washington University in St. Louis - Department of Neurology, Washington University in St. Louis - School of Medicine, University College London - Dementia Research Centre, University of New South Wales (UNSW), University of Rouen - Rouen University Hospital, University of Pittsburgh - Department of Neurology, University of Alabama at Birmingham, University of Melbourne - Florey Institute of Neuroscience and Mental Health, University of California, San Diego (UCSD) - Department of Neurology, University of Washington - Department of Neurology, Universitat de Barcelona, Université de Toulouse - CHU de Toulouse, St Vincent’s University Hospital (Ireland), Yale University - Department of Psychiatry, McGill University, University of British Columbia (UBC), University of Toronto, Pitié-Salpêtrière Hospital, Columbia University, Mayo Clinic, Washington University in St. Louis - Department of Neurology, Institute for Neurological Research (FLENI), Harvard University - Department of Neurology, Mayo Clinic - Florida - Department of Neurology, University College London, Butler Hospital, Niigata University - Department of Molecular Genetics, German Center for Neurodegenerative Diseases (DZNE), University of Ulsan - Department of Neurology, Emory University - Department of Neurology, Ludwig Maximilian University of Munich (LMU) - Department of Neurology, Universidad de Antioquia, Korea University, McGill University - McGill University Research Centre for Studies in Aging (MCSA), Neuroscience Research Australia and affiliation not provided to SSRN

Emory University - Department of Epidemiology, Emory University, Government of the United Kingdom - South London and Maudsley NHS Foundation Trust, Case Western Reserve University, Barcelona Institute of Science and Technology (BIST) - Centre for Genomic Regulation (CRG), affiliation not provided to SSRN, Stella Maris College, Harvard University - Boston Children’s Hospital, Hospital Israelita Albert Einstein, Fondazione Policlinico Universitario A. Gemelli IRCCS, Virginia Mason Medical Center - Down Syndrome Program, University of Calcutta - Cytogenetics and Genomics Research Unit, University College London - Great Ormond Street Institute of Child Health, Ludwig Maximilian University of Munich (LMU) - Department of Neurology, University of Toronto, Adult Down syndrome outpatient Unit, Department of Internal Medicine and Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Bar-Ilan University, Research Programme on Biomedical Informatics, Hospital del Mar Medical Research Institute and Universitat Pompeu Fabra, Institut Jérôme Lejeune, Saarland University, affiliation not provided to SSRN, affiliation not provided to SSRN, Emory University, King’s College London - Institute of Psychiatry, Psychology and Neuroscience and affiliation not provided to SSRN

Autonomous University of Barcelona, Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Fundació Catalana Síndrome de Down, Autonomous University of Barcelona, Fundació Catalana Síndrome de Down, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Autonomous University of Barcelona, Autonomous University of Barcelona, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Autonomous University of Barcelona, Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau, New York University (NYU), New York University (NYU), New York University (NYU), Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau, Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), University of Melbourne - Trinity College, Trinity College (Dublin), Avista CLG, Autonomous University of Barcelona, Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Trinity College (Dublin), Ludwig Maximilian University of Munich (LMU) - Department of Neurology, Institut Jérôme Lejeune, Hospital de la Santa Creu i Sant Pau and Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau)

University of Gothenburg - Department of Psychiatry and Neurochemistry, Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), University of Gothenburg - Department of Psychiatry and Neurochemistry, Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Ludwig Maximilian University of Munich (LMU) - Department of Neurology, Hospital de la Santa Creu i Sant Pau, University of Gothenburg - Department of Psychiatry and Neurochemistry, University of Gothenburg - Department of Psychiatry and Neurochemistry, Hospital de la Santa Creu i Sant Pau, University of Gothenburg - Department of Psychiatry and Neurochemistry, Hospital de la Santa Creu i Sant Pau, University of Gothenburg - Department of Psychiatry and Neurochemistry, Fundació Catalana Síndrome de Down, Ludwig Maximilian University of Munich (LMU), University of Gothenburg - Department of Psychiatry and Neurochemistry, Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), University of Gothenburg - Department of Psychiatry and Neurochemistry, University of Gothenburg - Department of Psychiatry and Neurochemistry and Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau)

Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Division of Biostatistics, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Division of Biostatistics, Washington University in St. Louis - Division of Biostatistics, Washington University in St. Louis - Division of Biostatistics, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Department of Radiology, Washington University in St. Louis - School of Medicine, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Mayo Clinic - Florida - Department of Neurology, Niigata University - Department of Molecular Genetics, University of Tokyo, Institute for Neurological Research (FLENI), Ludwig Maximilian University of Munich (LMU) - Department of Neurology, Ludwig Maximilian University of Munich (LMU) - Department of Neurology, Washington University in St. Louis - Knight Alzheimer Disease Research Center and affiliation not provided to SSRN

Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Department of Neurology, Washington University in St. Louis - Department of Neurology, Washington University in St. Louis - Department of Neurology, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Washington University in St. Louis - Knight Alzheimer Disease Research Center, Icahn School of Medicine at Mount Sinai - Department of Genetics and Genomic Sciences, Washington University in St. Louis - Department of Neurology, University of California, Irvine, School of Medicine, Department of Pediatrics, University of Wisconsin - Madison - Departments of Medical Physics and Psychiatry, Harvard University - Department of Neurology, Harvard University - Department of Neurology, Columbia University - Departments of Epidemiology and Neurology, University of California, Irvine, School of Medicine, Department of Pediatrics, Columbia University - Departments of Epidemiology and Neurology, University of Pittsburgh - Department of Psychiatry, University of Pittsburgh - Department of Psychiatry, Independent, Institute for Neurological Research (FLENI), Harvard University - Department of Neurology, Mayo Clinic - Florida - Department of Neurology, Mayo Clinic - Florida - Department of Neurology, German Center for Neurodegenerative Diseases (DZNE), Ludwig Maximilian University of Munich (LMU) - Department of Neurology, Edith Cowan University - School of Medical and Health Sciences, University of Melbourne - Florey Institute of Neuroscience and Mental Health, Osaka City University - Department of Clinical Neuroscience, University College London - Dementia Research Centre, University of Tokyo - Unit for Early and Exploratory Clinical Development, University of Southern California - Department of Neurology, Brown University - Memory and Aging Program, University of New South Wales (UNSW) - School of Medical Sciences (SoMS), Geriatrics Research Institute and Hospital, Independent and University of California, Irvine, School of Medicine, Department of Pediatrics

University of Calcutta, Emory University - Department of Epidemiology, Emory University, Harvard University - Boston Children’s Hospital, Barcelona Institute of Science and Technology (BIST) - Centre for Genomic Regulation (CRG), Stella Maris College, Case Western Reserve University - Department of Psychiatry, Virginia Mason Medical Center - Down Syndrome Program, Institut Jérôme Lejeune, affiliation not provided to SSRN, affiliation not provided to SSRN, Saarland University, Ludwig Maximilian University of Munich (LMU) - Department of Neurology, University College London - Great Ormond Street Institute of Child Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Emory University, King’s College London - Institute of Psychiatry, Psychology and Neuroscience, University of Calcutta - Cytogenetics and Genomics Research Unit and affiliation not provided to SSRN