University of Calcutta, Emory University - Department of Epidemiology, Emory University, Harvard University - Boston Children’s Hospital, Barcelona Institute of Science and Technology (BIST) - Centre for Genomic Regulation (CRG), Stella Maris College, Case Western Reserve University - Department of Psychiatry, Virginia Mason Medical Center - Down Syndrome Program, Institut Jérôme Lejeune, affiliation not provided to SSRN, affiliation not provided to SSRN, Saarland University, Ludwig Maximilian University of Munich (LMU) - Department of Neurology, University College London - Great Ormond Street Institute of Child Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Emory University, King’s College London - Institute of Psychiatry, Psychology and Neuroscience, University of Calcutta - Cytogenetics and Genomics Research Unit and affiliation not provided to SSRN