Emory University - Department of Epidemiology, Emory University, Government of the United Kingdom - South London and Maudsley NHS Foundation Trust, Case Western Reserve University, Barcelona Institute of Science and Technology (BIST) - Centre for Genomic Regulation (CRG), affiliation not provided to SSRN, Stella Maris College, Harvard University - Boston Children’s Hospital, Hospital Israelita Albert Einstein, Fondazione Policlinico Universitario A. Gemelli IRCCS, Virginia Mason Medical Center - Down Syndrome Program, University of Calcutta - Cytogenetics and Genomics Research Unit, University College London - Great Ormond Street Institute of Child Health, Ludwig Maximilian University of Munich (LMU) - Department of Neurology, University of Toronto, Adult Down syndrome outpatient Unit, Department of Internal Medicine and Instituto de Investigación Sanitaria La Princesa, Hospital Universitario de La Princesa, Bar-Ilan University, Research Programme on Biomedical Informatics, Hospital del Mar Medical Research Institute and Universitat Pompeu Fabra, Institut Jérôme Lejeune, Saarland University, affiliation not provided to SSRN, affiliation not provided to SSRN, Emory University, King’s College London - Institute of Psychiatry, Psychology and Neuroscience and affiliation not provided to SSRN

Autonomous University of Barcelona, Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Fundació Catalana Síndrome de Down, Autonomous University of Barcelona, Fundació Catalana Síndrome de Down, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Autonomous University of Barcelona, Autonomous University of Barcelona, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Autonomous University of Barcelona, Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau, New York University (NYU), New York University (NYU), New York University (NYU), Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau, Hospital de la Santa Creu i Sant Pau, Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), University of Melbourne - Trinity College, Trinity College (Dublin), Avista CLG, Autonomous University of Barcelona, Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Trinity College (Dublin), Ludwig Maximilian University of Munich (LMU) - Department of Neurology, Institut Jérôme Lejeune, Hospital de la Santa Creu i Sant Pau and Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau)

University of Calcutta, Emory University - Department of Epidemiology, Emory University, Harvard University - Boston Children’s Hospital, Barcelona Institute of Science and Technology (BIST) - Centre for Genomic Regulation (CRG), Stella Maris College, Case Western Reserve University - Department of Psychiatry, Virginia Mason Medical Center - Down Syndrome Program, Institut Jérôme Lejeune, affiliation not provided to SSRN, affiliation not provided to SSRN, Saarland University, Ludwig Maximilian University of Munich (LMU) - Department of Neurology, University College London - Great Ormond Street Institute of Child Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Emory University, King’s College London - Institute of Psychiatry, Psychology and Neuroscience, University of Calcutta - Cytogenetics and Genomics Research Unit and affiliation not provided to SSRN