University of Nottingham - Division of Rheumatology, Orthopaedics and Dermatology, University College London - Institute of Cardiovascular Science, affiliation not provided to SSRN, University College London, University of Nottingham, University of Nottingham, University of Nottingham, University of Nottingham, University of Nottingham, Queen Mary University of London - Blizard Institute, National Infection Service, Public Health England, Queen Mary University of London - Centre for Genomics and Child Health, Government of the United Kingdom - Barts Health NHS Trust, King's College London - Department of Twin Research and Genetic Epidemiology, University of Nottingham, University College London - Division of Infection and Immunity, Nottingham Digestive Disease Centre, University of Nottingham School of Medicine, Barts Heart Centre, St. Bartholomew's Hospital, University of Nottingham and Government of the United Kingdom - Barts Health NHS Trust