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Orian S. Shirihai

University of California, Los Angeles (UCLA) - Department of Medicine

Los Angeles, CA

United States

  • University of California, Los Angeles (UCLA) - Department of Medicine

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Patient-Specific iPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease

Number of pages: 86 Posted: 30 Dec 2020
Konstantinos-Dionysios Alysandratos, Scott J. Russo, Anton Petcherski, Evan P. Taddeo, Rebeca Acín-Pérez, Carlos Villacorta-Martin, J. C. Jean, Surafel Mulugeta, Benjamin C. Blum, Ryan M. Hekman, Kasey Minakin, Marall Vedaie, Seunghyi Kook, Jennifer A. Wambach, F. Sessions Cole, Aaron Hamvas, Lisa R. Young, Marc Liesa, Andrew Emili, Susan H. Guttentag, Orian S. Shirihai, Michael F. Beers and Darrell N. Kotton
Boston University - Center for Regenerative Medicine, University of Pennsylvania - Division of Pulmonary, Allergy, and Critical Care, University of California, Los Angeles (UCLA) - Department of Medicine, University of California, Los Angeles (UCLA) - Department of Medicine, University of California, Los Angeles (UCLA) - Department of Medicine, Boston University - Center for Regenerative Medicine, Boston University - Center for Regenerative Medicine, University of Pennsylvania - Division of Pulmonary, Allergy, and Critical Care, Boston University - Department of Biochemistry, Boston University - Department of Biochemistry, Boston University - Center for Regenerative Medicine, Boston University - Center for Regenerative Medicine, Vanderbilt University - Department of Pediatrics, Washington University in St. Louis - Division of Newborn Medicine, Washington University in St. Louis - Division of Newborn Medicine, Northwestern University - Department of Pediatrics, Children’s Hospital of Philadelphia - Division of Pulmonary and Sleep Medicine, Boston University - Department of Medicine, Boston University - Department of Biochemistry, Vanderbilt University - Department of Pediatrics, University of California, Los Angeles (UCLA) - Department of Medicine, University of Pennsylvania - Division of Pulmonary, Allergy, and Critical Care and Boston University - Center for Regenerative Medicine
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induced pluripotent stem cells (iPSCs), iPSC-derived alveolar epithelial type 2 cells (iAEC2s), surfactant protein C (SFTPC), autophagy, proteostasis, bioenergetics, metabolic reprogramming, NF-κB