University of Birmingham - Institute of Metabolism and Systems Research, University of Oxford - Hypoxia and Angiogenesis Group, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Tartu - Centre of Excellence for Genomics and Translational Medicine, University of Tartu - Centre of Excellence for Genomics and Translational Medicine, University of Birmingham - University Hospital Birmingham NHS Foundation Trust and Institute of Cancer and Genomic Science, University of Glasgow - Beatson Institute for Cancer Research, University of Tartu - Centre of Excellence for Genomics and Translational Medicine, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Oxford - Hypoxia and Angiogenesis Group and University of Birmingham - Institute of Metabolism and Systems Research