Tulane University - Section of Endocrinology and Metabolism, Tulane University - Section of Endocrinology and Metabolism, University of Birmingham - Institute of Metabolism and Systems Research, Tulane University - Section of Endocrinology and Metabolism, University of Birmingham, University of Miami, affiliation not provided to SSRN, University of Birmingham, affiliation not provided to SSRN, affiliation not provided to SSRN, Tulane University - Section of Endocrinology and Metabolism, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Washington University in St. Louis - Department of Molecular Microbiology, affiliation not provided to SSRN, University of Texas at Houston - MD Anderson Cancer Center, Tulane University - Deming Department of Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, Cornell University - Weill Cornell Medicine, Cornell University - Weill Cornell Medicine, Tulane University School of Medicine, Tulane University School of Medicine, affiliation not provided to SSRN, Imperial College London, University of Miami - Division of Endocrinology, Diabetes and Metabolism, University of Birmingham - Institute of Metabolism and Systems Research and Tulane University - Section of Endocrinology and Metabolism

University of Birmingham - Institute of Metabolism and Systems Research, University of Oxford - Hypoxia and Angiogenesis Group, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Tartu - Centre of Excellence for Genomics and Translational Medicine, University of Tartu - Centre of Excellence for Genomics and Translational Medicine, University of Birmingham - University Hospital Birmingham NHS Foundation Trust and Institute of Cancer and Genomic Science, University of Glasgow - Beatson Institute for Cancer Research, University of Tartu - Centre of Excellence for Genomics and Translational Medicine, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Oxford - Department of Medical Oncology and University of Birmingham - Institute of Metabolism and Systems Research

University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Lille II - U1190-EGID, University of Lille II - U1190-EGID, University of Lille II - U1190-EGID, Università Vita-Salute San Raffaele - San Raffaele Diabetes Research Institute, Università Vita-Salute San Raffaele - San Raffaele Diabetes Research Institute, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism, Imperial College London - Section of Cell Biology and Functional Genomics, University of Montreal - Faculty of Medicine, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham - Institute of Metabolism and Systems Research and University of Birmingham - Institute of Metabolism and Systems Research