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Laura H. Heitman

Leiden University - Leiden Academic Centre for Drug Research

SCHOLARLY PAPERS

3

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217

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0

Scholarly Papers (3)

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1.

Impact of Cancer-Associated Mutations in CC Chemokine Receptor 2 on Receptor Function and Antagonism

Number of pages: 33 Posted: 03 Nov 2022
Lisa S. den Hollander, Olivier J.M. Béquignon, Xuesong Wang, Kim van Wezel, Jeremy Broekhuis, Marina Gorostiola González, Karin E. de Visser, Adriaan P. IJzerman, Gerard J. P. van Westen and Laura H. Heitman
Leiden University - Leiden Academic Centre for Drug Research, Leiden University - Leiden Academic Centre for Drug Research, Leiden University - Leiden Academic Centre for Drug Research, Leiden University - Leiden Academic Centre for Drug Research, Leiden University - Leiden Academic Centre for Drug Research, Leiden University - Leiden Academic Centre for Drug Research, Leiden University - Leiden Academic Centre for Drug Research, Leiden University - Leiden Academic Centre for Drug Research, Leiden University - Leiden Academic Centre for Drug Research and Leiden University - Leiden Academic Centre for Drug Research
Downloads 105 (669,616)

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CC chemokine receptor 2, Cancer, mutation, orthosteric and allosteric antagonists

2.

Cc Chemokine Receptor 2 is Allosterically Modulated by Sodium Ions and Amiloride Derivatives Through a Distinct Sodium Ion Binding Site

Number of pages: 29 Posted: 22 Mar 2024
Lisa S. den Hollander, Annelien J.M. Zweemer, Olivier J.M. Béquignon, Dora M. Hammerl, Bente T.M. Bleijs, Margo Veenhuizen, Wernard J.F. Lantsheer, Bobby Chau, Gerard J. P. van Westen, Adriaan P. IJzerman and Laura H. Heitman
Leiden University - Leiden Academic Centre for Drug Research, affiliation not provided to SSRN, Leiden University - Leiden Academic Centre for Drug Research, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Leiden University - Leiden Academic Centre for Drug Research, Leiden University - Leiden Academic Centre for Drug Research and Leiden University - Leiden Academic Centre for Drug Research
Downloads 57 (1,000,027)

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Chemokine receptor, sodium ion binding site, G protein-coupled receptor, allosterism

3.

Pharmacological Profiling of Antagonists for Cc Chemokine Receptor 5: Evidence for Allosterism, Biased Antagonism and Probe Dependence

Number of pages: 50 Posted: 13 Aug 2025
Yao Yao, Gijs Stavast, Cas van der Horst, Natalia V. Ortiz Zacarías and Laura H. Heitman
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and Leiden University - Leiden Academic Centre for Drug Research
Downloads 55 (1,097,529)

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CC chemokine receptor 5, pharmacological profiling, orthosteric antagonist, allosteric antagonist, probe dependence, biased antagonism