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Yongheng Chen

Central South University - NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs

China

  • Central South University - NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs

SCHOLARLY PAPERS

3

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189

TOTAL CITATIONS

0

Scholarly Papers (3)

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1.

Design, Synthesis and Biological Evaluation of 5-Amino-1h-Pyrazole-4-Carboxamide Derivatives as Pan-Fgfr Covalent Inhibitors

Number of pages: 25 Posted: 19 Apr 2024
Wuqing Deng, Xiaojuan Chen, Hong Liang, Xiaojuan Song, Shuang Xiang, Jing Guo, Zhengchao Tu, Yang Zhou, Yongheng Chen and Xiaoyun Lu
Jinan University, affiliation not provided to SSRN, Jinan University, Jinan University, Jinan University, Jinan University, Jinan University, Jinan University, Central South University - NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs and Jinan University - International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development
Downloads 67 (899,324)

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Pan-FGFR inhibitors, covalent binding, 5-amino-1H-pyrazole-4-carboxamide, Gatekeeper mutation, structure-based drug design.

2.

Site-Specific N-Terminal Pegylation-Based Controlled Release of Biotherapeutics: An Application for Glp-1 Delivery to Improve Pharmacokinetics and Prolong Hypoglycemic Effects

Number of pages: 22 Posted: 28 Mar 2022
Qianmeng Lin, Xuan Xia, Jun Li, Zhan Zhou and Yongheng Chen
Central South University, Central South University, Central South University, Central South University - Research Center for Molecular Metabolomics and Central South University - NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs
Downloads 65 (924,743)

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PEGylation, controlled release, site-specific modification, pharmacokinetics, GLP-1, hypoglycemic effect

3.

Optimization of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors for Wild-Type and Mutant Fgfr4

Number of pages: 36 Posted: 17 Jan 2025
Jing Guo, Xiaojuan Chen, Xiaofei Li, Min Shao, Xiaojuan Song, Lin Zhang, Shengjie Huang, Adam V. Patterson, Jeff B. Smaill, Yang Zhou, Xiangrong Yu, Yongheng Chen and Xiaoyun Lu
Jinan University, affiliation not provided to SSRN, Jinan University, Jinan University, Jinan University, affiliation not provided to SSRN, Jinan University, University of Auckland, University of Auckland, Jinan University, Jinan University - Department of Radiology, Central South University - NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs and Jinan University - International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development
Downloads 57 (989,921)

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FGFR4, hepatocellular carcinoma, clinical resistance mutations, covalent binding