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Yang Zhou

Jinan University

Huang Pu Da Dao Xi 601, Tian He District

Guangzhou, 510632

China

SCHOLARLY PAPERS

7

DOWNLOADS

419

TOTAL CITATIONS

0

Scholarly Papers (7)

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1.

Discovery of New Lenalidomide Derivatives as Potent and Selective Gspt1 Degraders

Number of pages: 35 Posted: 19 May 2023
Yiying Wei, Xinxin Xu, Minchuan Jiang, Yongxing Wan, Yang Zhou, Zhen Wang, Zhang Zhang, Fengtao Zhou and Ke Ding
Jinan University, Jinan University, Jinan University, Livzon Pharmaceutical Group Inc, Jinan University, Chinese Academy of Sciences (CAS), Jinan University, Jinan University and Jinan University
Downloads 113 (626,371)

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GSPT1, protein degradation, molecular glue, cancer

2.

Design, Synthesis and Biological Evaluation of 5-Amino-1h-Pyrazole-4-Carboxamide Derivatives as Pan-Fgfr Covalent Inhibitors

Number of pages: 25 Posted: 19 Apr 2024
Wuqing Deng, Xiaojuan Chen, Hong Liang, Xiaojuan Song, Shuang Xiang, Jing Guo, Zhengchao Tu, Yang Zhou, Yongheng Chen and Xiaoyun Lu
Jinan University, affiliation not provided to SSRN, Jinan University, Jinan University, Jinan University, Jinan University, Jinan University, Jinan University, Central South University - NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs and Jinan University - International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development
Downloads 67 (899,324)

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Pan-FGFR inhibitors, covalent binding, 5-amino-1H-pyrazole-4-carboxamide, Gatekeeper mutation, structure-based drug design.

3.

Optimization of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors for Wild-Type and Mutant Fgfr4

Number of pages: 36 Posted: 17 Jan 2025
Jing Guo, Xiaojuan Chen, Xiaofei Li, Min Shao, Xiaojuan Song, Lin Zhang, Shengjie Huang, Adam V. Patterson, Jeff B. Smaill, Yang Zhou, Xiangrong Yu, Yongheng Chen and Xiaoyun Lu
Jinan University, affiliation not provided to SSRN, Jinan University, Jinan University, Jinan University, affiliation not provided to SSRN, Jinan University, University of Auckland, University of Auckland, Jinan University, Jinan University - Department of Radiology, Central South University - NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs and Jinan University - International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development
Downloads 57 (989,921)

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FGFR4, hepatocellular carcinoma, clinical resistance mutations, covalent binding

4.

Discovery of 1-Hydroxy-2-Methylquinolin-4(1H)-One Derivatives as New Cytochrome bd Oxidase Inhibitors for Tuberculosis Therapy

Number of pages: 33 Posted: 23 Sep 2022
Yang Zhou, Min Shao, Weiwei Wang, Chen-Yi Cheung, Yu Wu, Hang Yu, Xianglong Hu, Gregory M. Cook, Hongri Gong and Xiaoyun Lu
Jinan University, Jinan University, Nankai University, University of Otago, Jinan University, Jinan University, Jinan University, University of Otago, Nankai University and Jinan University - International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development
Downloads 55 (1,010,164)

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Tuberculosis, cytochrome bd Oxidase, inhibitors, combinational therapy

5.

Discovery of the First Potent Ror1 Degrader for the Treatment of Non-Small Cell Lung Cancer

Number of pages: 55 Posted: 13 Nov 2024
Fengtao Zhou, Jinlin Li, Lin Li, Caiyun Hou, Zhaodi Tian, Yang Zhou, Jinwei Zhang, xiaomei Ren, Zhen Wang, weixue huang and Ke Ding
Jinan University, Jinan University, Chinese Academy of Sciences (CAS) - Shanghai Institute of Organic Chemistry, Jinan University, Chinese Academy of Sciences (CAS) - Shanghai Institute of Organic Chemistry, Jinan University, Chinese Academy of Sciences (CAS), Chinese Academy of Sciences (CAS) - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CAS), Chinese Academy of Sciences (CAS) - Shanghai Institute of Organic Chemistry and Jinan University
Downloads 52 (1,041,696)

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ROR1, Pseudokinase, PROTACs, Protein Degradation, Apoptosis, Proliferation, NSCLC

6.

Discovery of 5-Aminopyrido[2,3- d]Pyrimidin-7(8 H)-One Derivatives as New Hematopoietic Progenitor Kinase 1 (HPK1) Inhibitors

Number of pages: 61 Posted: 30 Jan 2024
Qiu Xiaorong, Rong Liu, Huan Ling, Yang Zhou, xiaomei Ren, Fengtao Zhou, Jinwei Zhang, weixue huang, Zhen Wang and Ke ding
Chinese Academy of Sciences (CAS) - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CAS) - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CAS) - Shanghai Institute of Organic Chemistry, Jinan University, Chinese Academy of Sciences (CAS) - Shanghai Institute of Organic Chemistry, Jinan University, Chinese Academy of Sciences (CAS), Chinese Academy of Sciences (CAS) - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CAS) and Chinese Academy of Sciences (CAS) - Shanghai Institute of Organic Chemistry
Downloads 44 (1,133,231)

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HPK1, Kinase inhibitor, Cancer immunotherapy, Selectivity, Cocrystal structure

7.

Discovery of Czy43 as a New Small-Molecule Degrader of Pseudokinase Her3

Number of pages: 41 Posted: 13 Nov 2024
Zhiyuan Chen, Rui He, Shengjie Huang, Yang Zhou, Zhang Zhang, Zhen Wang and Ke ding
affiliation not provided to SSRN, Jinan University, Jinan University, Jinan University, Jinan University, Chinese Academy of Sciences (CAS) and Chinese Academy of Sciences (CAS) - Shanghai Institute of Organic Chemistry
Downloads 31 (1,304,549)

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HER3, pseudokinase, hydrophobic tag degrader, Breast cancer, autophagy