Stellenbosch University - Division of Molecular Biology and Human Genetics, University of Antwerp - Centre for Population, Family, and Health, Stellenbosch University - Division of Molecular Biology and Human Genetics, Natera, Inc., Stellenbosch University - Division of Molecular Biology and Human Genetics, Stellenbosch University - Division of Molecular Biology and Human Genetics, University of California, San Francisco (UCSF) - Division of Pulmonary and Critical Care Medicine, Stellenbosch University - Division of Molecular Biology and Human Genetics, National Health Laboratory Services (NHLS), Stellenbosch University - Division of Molecular Biology and Human Genetics, Médecins sans Frontières, Eshowe, South Africa, The Translational Genomics Research Institute (TGen), The Translational Genomics Research Institute (TGen), University of Antwerp - Centre for Population, Family, and Health, University of Basel - Swiss Tropical and Public Health Institute, Institute of Tropical Medicine - Mycobacteriology Unit, Brooklyn Chest Hospital, University of Cape Town (UCT) - Centre for Lung Infection and Immunity, Médecins sans Frontières, Eshowe, South Africa, Stellenbosch University - Division of Molecular Biology and Human Genetics, University of California, San Francisco (UCSF) - Division of Pulmonary and Critical Care Medicine, University of Cape Town (UCT) - Division of Medical Microbiology and Stellenbosch University - DST/NRF Centre of Excellence for Biomedical Tuberculosis Research