European Organisation for Research and Treatment of Cancer (EORTC), European Organisation for Research and Treatment of Cancer (EORTC), affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Pfizer, Inc., affiliation not provided to SSRN, Boehringer Ingelheim International GmbH, University Medical Center Groningen - Department of Medical Oncology, Leeds Teaching Hospitals NHS Trust, KU Leuven, affiliation not provided to SSRN, affiliation not provided to SSRN, European Medicines Agency and Merck Healthcare KGaA

European Organisation for Research and Treatment of Cancer (EORTC), European Organisation for Research and Treatment of Cancer (EORTC), University of Amsterdam - University Medical Center, Karolinska Institutet, University of Copenhagen, Faculty of Health and Medical Sciences, Department of Public Health, University Hospital Magdeburg, Adelphi Values, Patient-Centered Outcomes, University of Leeds, Leiden University - Leiden University Medical Center (LUMC), Medical University of Graz, University Medical Center Mainz, Maria Sklodowska-Curie National Research Institute of Oncology, Innsbruck Institute of Patient-centered Outcome Research (IIPCOR), University of Southampton, Princess Máxima Center for Pediatric Oncology, University Hospital Regensburg - Center for Clinical Studies, University of Amsterdam - Amsterdam University Medical Centers, Leiden University - Leiden University Medical Center (LUMC), The University of Sydney - School of Psychology and European Organisation for Research and Treatment of Cancer (EORTC)

University of Amsterdam - Amsterdam University Medical Centers, European Organisation for Research and Treatment of Cancer (EORTC), European Organisation for Research and Treatment of Cancer (EORTC), Leiden University, Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC), KU Leuven, Sorbonne University, Utrecht University - Department of Medical Oncology, University of Amsterdam - Amsterdam University Medical Centers, Heidelberg University - University Hospital Heidelberg, University College Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, European Organisation for Research and Treatment of Cancer (EORTC), European Organisation for Research and Treatment of Cancer (EORTC), European Organisation for Research and Treatment of Cancer (EORTC), Erasmus MC - Brain Tumor Centre and Independent

affiliation not provided to SSRN, Leiden University - Leiden University Medical Center (LUMC), Leiden University - Department of Medical Statistics, Erasmus MC - Brain Tumor Centre, Netherlands Cancer Institute - Division of Psychosocial Research and Epidemiology, affiliation not provided to SSRN, affiliation not provided to SSRN, KU Leuven, European Organisation for Research and Treatment of Cancer (EORTC), EORTC Headquarters, University of Bonn - University Hospital Bonn (UKB), University Hospital Zurich, affiliation not provided to SSRN, Université de Lille - Laboratoire Protéomique, affiliation not provided to SSRN, affiliation not provided to SSRN, Medical University of Vienna, affiliation not provided to SSRN, affiliation not provided to SSRN, International BrainTumour Alliance, IRCCS Regina Elena National Cancer Institute, affiliation not provided to SSRN, University of Amsterdam - Amsterdam University Medical Centers, affiliation not provided to SSRN, University Hospital Zurich, Universitätsklinikum Leipzig, University of Lausanne, Heidelberg University - University Hospital Heidelberg, University Hospital Zurich, Leiden University - Leiden University Medical Center (LUMC) and affiliation not provided to SSRN