Leeds Teaching Hospitals NHS Trust, Cardiff University - Centre for Trials Research, University of Leeds - Leeds Institute of Clinical Trials Research, University College London, National Radiotherapy Trials QA (RTTQA) Group, National Radiotherapy Trials QA (RTTQA) Group, Independent, University of Leeds - Leeds Institute of Clinical Trials Research, St James’s University Hospital, University of Leeds - Leeds Institute of Clinical Trials Research, University Hospitals Bristol - University Hospitals Bristol and Weston NHS Foundation Trust, Government of the United Kingdom, Department of Health, National Health Service (NHS), Mount Vernon Cancer Centre Northwood, King’s College London, University College London - Department of Medical Physics and Biomedical Engineering, University Hospitals Sussex NHS Foundation Trust, Government of the United Kingdom - Oxford University Hospitals NHS Foundation Trust, NHS Foundation Trust - Royal Marsden Hospital, The University of Manchester - Manchester Cancer Research Centre, University of Leeds - Institute of Medical Research, University of Leeds, University of Leeds - Leeds Institute of Clinical Trials Research, University of Surrey, University Hospitals Sussex NHS Foundation Trust, Leeds Teaching Hospitals NHS Trust, University of Leeds - Institute of Medical Research and Mount Vernon Hospital

Leeds Teaching Hospitals NHS Trust, University of Oslo - Oslo University Hospital, Maastricht University - GROW School for Oncology and Reproduction, Maastricht University - GROW School for Oncology and Reproduction, Netherlands Cancer Institute Antoni van Leeuwenhoek, Maastricht University, University of New South Wales (UNSW), Catholic University of the Sacred Heart, Rome, Leeds Teaching Hospitals NHS Trust, University of Oslo - Oslo University Hospital, NHS Foundation Trust - Cambridge University Hospitals, Manchester Academic Health Sciences Centre - The Christie NHS Foundation Trust, Goethe University Frankfurt - University Hospital Frankfurt, RWTH Aachen University - University Medical Center Aachen, Government of the United Kingdom - Oxford University Hospitals NHS Foundation Trust, Champalimaud Foundation, Greater Poland Cancer Centre, Government of the United Kingdom - Hull University Teaching Hospitals NHS Trust, Leeds Teaching Hospitals NHS Trust, University of Leeds - Institute of Medical Research, Cardiff University - School of Engineering, Bank of Cyprus Oncology Centre, University of Oslo, Maastricht University - GROW School for Oncology and Reproduction, Leeds Teaching Hospitals NHS Trust and Independent

European Organisation for Research and Treatment of Cancer (EORTC), European Organisation for Research and Treatment of Cancer (EORTC), affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Pfizer, Inc., affiliation not provided to SSRN, Boehringer Ingelheim International GmbH, University Medical Center Groningen - Department of Medical Oncology, Leeds Teaching Hospitals NHS Trust, KU Leuven, affiliation not provided to SSRN, affiliation not provided to SSRN, European Medicines Agency and Merck Healthcare KGaA

University of Leeds, affiliation not provided to SSRN, Fondazione IRCCS Istituto Nazionale dei Tumori, Fondazione IRCCS Istituto Nazionale dei Tumori, German Cancer Research Center (DKFZ), affiliation not provided to SSRN, École Normale Supérieure - PSL Research University - Institut Curie, Fondazione IRCCS Istituto Nazionale dei Tumori, Fondazione IRCCS Istituto Nazionale dei Tumori, Istituti Fisioterapici Ospitalieri (IFO) - IRCCS Regina Elena National Cancer Institute, University of Copenhagen - Copenhagen University Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, Autonomous University of Barcelona - Health Services Research Unit, Gustave Roussy, Fondazione IRCCS Istituto Nazionale dei Tumori, Autonomous University of Barcelona - Hospital del Mar, Gustave Roussy, University of Copenhagen, Faculty of Health and Medical Sciences, Department of Public Health, affiliation not provided to SSRN, Netherlands Cancer Institute, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Gustave Roussy, Copenhagen University - Copenhagen University Hospital, SporeData Inc, affiliation not provided to SSRN, Fondazione IRCCS Istituto Nazionale dei Tumori, UNICANCER, Netherlands Cancer Institute, affiliation not provided to SSRN, affiliation not provided to SSRN, Netherlands Cancer Institute, Gustave Roussy, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Leeds and Leeds Teaching Hospitals NHS Trust