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Mingzhu Lu

Fudan University

Beijing West District Baiyun Load 10th

Shanghai, 100045

China

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Scholarly Papers (1)

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Discovery of a High Potent PIM Kinase Inhibitor for Acute Myeloid Leukemia Based on N-Pyridinyl Amide Scaffold by Optimizing the Fragments Toward to Lys67 and Asp128/Glu171

Number of pages: 50 Posted: 24 Apr 2023
Ruiqing Xiang, Mingzhu Lu, Tianze Wu, Chengbin Yang, Yu Jia, Xiaofeng Liu, Mingli Deng, Yu Ge, Jun Xu, Tong Cai, Yun Ling and Yaming Zhou
Fudan University, Fudan University, Fudan University, Fudan University - Department of Pharmaceutics, Fudan University, Fudan University, Fudan University - Department of Chemistry, SD Chem, Inc., ABA Chemicals Corporation, ABA Chemicals Corporation, Fudan University - Department of Chemistry and Fudan University - Department of Chemistry
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Abstract:

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N-pyridinyl amide scaffold, PIM inhibitors, Structure-activity relationship, Acute myeloid leukemia