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John Pascal

University of Montreal

C.P. 6128 succursale Centre-ville

Montreal, H3C 3J7

Canada

SCHOLARLY PAPERS

2

DOWNLOADS

117

TOTAL CITATIONS

1

Scholarly Papers (2)

1.

DNA Pro-Retention Modulators of PARP1 Overcome Primary and Acquired Resistance to Clinical PARP Inhibitors

Number of pages: 48 Posted: 26 Sep 2025
Oregon Health and Science University, Oregon Health and Science University, University of Colorado at Boulder - Department of Biochemistry, University of Montreal, University of Pennsylvania, University of Pennsylvania, University of Pennsylvania, University of Montreal, University of Colorado at Boulder - Department of Biochemistry, University of Montreal, Oregon Health and Science University, Tilikum Therapeutics, Tilikum Therapeutics, Tilikum Therapeutics, Tilikum Therapeutics, Ludwig Maximilian University of Munich (LMU), Ludwig Maximilian University of Munich (LMU), University of Colorado at Boulder - Department of Biochemistry, University of Pennsylvania - Department of Biochemistry and Biophysics, University of Montreal, Oregon Health and Science University and Independent
Downloads 87 (765,566)

Abstract:

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Poly(ADP-ribose) polymerases (PARPs), NAD+-competitive inhibitors, Allosteric regulation, PARP inhibitor resistance, DNA damage response (DDR), Non-enzymatic functions, Synthetic lethality

2.

A PARP2-Specific Active Site Α-Helix Melts to Permit DNA Damage-Induced Enzymatic Activation

Number of pages: 34 Posted: 21 May 2024
University of Pennsylvania, University of Pennsylvania, University of Montreal, St. John's University, University of Montreal and University of Pennsylvania
Downloads 30 (1,318,317)
Citation 1

Abstract:

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PARP enzymes, DNA damage detection, DNA damage, PARylation, PARPi, PARP1, PARP2, Deuterium exchange, mass spectrometry