University of Milan, University of Milan, affiliation not provided to SSRN, affiliation not provided to SSRN, Sapienza University of Rome, Academia Sinica, University of Milan, University of Milan - Department of Biosciences, University of Milan, University of Milan, University of Milan - Department of Biosciences, University of Pavia - Department of Molecular Medicine, University of Pavia, University of Pavia - Department of Molecular Medicine, Sapienza University of Rome, Academia Sinica - Institute of Biological Chemistry, Istituto di Ricerche Farmacologiche Mario Negri IRCCS and University of Milan - Department of Biosciences