Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Laboratorio di Malattie Neurologiche, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, University of Milano-Bicocca, University of Milano-Bicocca, University of Milano-Bicocca, University of Milano-Bicocca, University of Milano-Bicocca, University of Milano-Bicocca, Catholic University of Milan, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, University of Brescia - Neurology Unit, Spedali Civili di Brescia, University of Brescia - Department of Clinical and Experimental Sciences, Spedali Civili di Brescia, Spedali Civili di Brescia, University of Campania Federico II, Vanvitelli University of Campania Luigi Vanvitelli, Vanvitelli University of Campania Luigi Vanvitelli, Vanvitelli University of Campania Luigi Vanvitelli, Vanvitelli University of Campania Luigi Vanvitelli, ASST Lecco - Neurosciences Department, ASST Lecco - Neurosciences Department, ASST Lecco - Neurosciences Department, SOC Neurologia Ospedale S. Stefano Prato Azienda USL Toscana Centro, SOC Neurologia Ospedale S. Stefano Prato Azienda USL Toscana Centro, SOC Neurologia Ospedale S. Stefano Prato Azienda USL Toscana Centro, IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), University of Milano-Bicocca - School of Medicine and Surgery and University of Milano-Bicocca

University of Cincinnati - Department of Neuroradiology, Universita di Cagliari -Department of Neuroradiology, University of Cincinnati - Department of Neuroradiology, University of Brescia -Department of Neuroradiology, Istituto G. Gaslini Children Hospital Scientific Institute - Department of Pediatric Neuroradiology, University of Cincinnati - Department of Neuroradiology, University of Cincinnati - Department of Neurology, Cincinnati Children's Hospital Medical Center - Department of Epidemiology and Biostatistics, University of Eastern Piedmont - Department of Neuroradiology, Cincinnati Children's Hospital Medical Center - Department of Pediatrics, Università degli Studi di Sassari - Department of Neuroradiology, University of Brescia - Department of Neurology, University of Brescia - Department of Neurology, University of Brescia - Neurology Unit and University of Brescia -Department of Neuroradiology

University of Brescia - Department of Clinical and Experimental Sciences, University of Brescia - Department of Clinical and Experimental Sciences, University of Brescia - Department of Clinical and Experimental Sciences, University of Brescia - Department of Clinical and Experimental Sciences, University of Brescia - Department of Molecular and Translational Medicine, ASST-Spedali Civili of Brescia, ASST-Spedali Civili of Brescia, University of Brescia - Department of Clinical and Experimental Sciences, University of Brescia - Department of Clinical and Experimental Sciences, University of Brescia - Department of Clinical and Experimental Sciences, University of Brescia, University of Gothenburg - Department of Psychiatry and Neurochemistry, University of Gothenburg - Department of Psychiatry and Neurochemistry, University of Gothenburg - Department of Psychiatry and Neurochemistry, University of Brescia - Department of Molecular and Translational Medicine, ASST-Spedali Civili of Brescia and University of Brescia - Neurology Unit

Government of the United States of America - Neuromuscular Diseases Research Section, University of Sheffield, Government of the United States of America - Neuromuscular Diseases Research Section, University of Sheffield, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, National Institutes of Health, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, Government of the United States of America - National Institute on Aging (NIA), National Institute on Aging (NIA) - Computational Biology Group, King’s College London, National Institute on Aging - Neuromuscular Diseases Research Section, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Milan - IRCCS Istituto Auxologico Italiano, University of Piemonte Orientale, Utrecht University - University Medical Center (Utrecht), Utrecht University - Department of Neurology, Koc University, Koc University, National Institutes of Health, Government of the United States of America - National Institute on Aging (NIA), University of Turin, University of Milan, King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Milan - IRCCS Istituto Auxologico Italiano, University of Milan, University of Milan - IRCCS Istituto Auxologico Italiano, University of Piemonte Orientale, University Medical Center Utrecht - Department of Neurology, King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Padova, University of Brescia, University of Brescia, University of Brescia - Neurology Unit, IRCCS Mondino Foundation Pavia, Sapienza University of Rome, University of Ferrara, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, Università di Modena e Reggio Emilia, Istituti Clinici Scientifici Maugeri IRCCS, Istituti Clinici Scientifici Maugeri IRCCS, Agenzia Nazionale per i Servizi Sanitari Regionali - “S. Chiara” Hospital, University of Campania “Luigi Vanvitelli”, AV4 ASUR Marche, University of Turin, University of Turin, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Università degli Studi di Milano, Università degli Studi di Milano, University of Pavia, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, Queen's University, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), King’s College London - Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London - Department of Biostatistics & Health Informatics, Uniformed Services University of the Health Sciences - Department of Anatomy, Physiology and Genetics, Government of the United States of America - National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Neurological Disorders and Stroke - Neurodegenerative Diseases Research Unit, King’s College London - Department of Basic and Clinical Neuroscience, Utrecht University - Department of Neurology, Trinity College (Dublin), Trinity College (Dublin) - Academic Unit of Neurology, University of Milan, University of Padova, University of Piemonte Orientale, UK-Dementia Research Institute at University College London, University of Edinburgh, University of Milan - IRCCS Istituto Auxologico Italiano, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, National Institute of Neurological Disorders and Stroke - DIR Bioinformatics Section, Government of the United States of America - National Cancer Institute, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, University of Pisa, University of Milan, Koc University, Utrecht University - Department of Neurology, University of Montpellier, Emory University - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, Government of the United States of America - National Institute on Aging (NIA), Government of the United States of America - National Institute on Aging (NIA), King’s College London - Maurice Wohl Clinical Neuroscience Institute, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), Government of the United States of America - National Institute on Aging (NIA) and Government of the United States of America - Neuromuscular Diseases Research Section

National Institutes of Health, University of Sheffield, Government of the United States of America - Neuromuscular Diseases Research Section, University of Sheffield, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, National Institutes of Health, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, Government of the United States of America - National Institute on Aging (NIA), National Institute on Aging (NIA) - Computational Biology Group, King’s College London, National Institute on Aging - Neuromuscular Diseases Research Section, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Milan - IRCCS Istituto Auxologico Italiano, University of Piemonte Orientale, Utrecht University - University Medical Center (Utrecht), Utrecht University - Department of Neurology, Koc University, Koc University, National Institutes of Health, Government of the United States of America - National Institute on Aging (NIA), University of Turin, University of Milan, Utrecht University - University Medical Center (Utrecht), King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Milan - IRCCS Istituto Auxologico Italiano, University of Milan, University of Milan - IRCCS Istituto Auxologico Italiano, University of Piemonte Orientale, University Medical Center Utrecht - Department of Neurology, King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Padova, University of Brescia, University of Brescia, University of Brescia - Neurology Unit, IRCCS Mondino Foundation Pavia, Sapienza University of Rome, University of Ferrara, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, Università di Modena e Reggio Emilia, Istituti Clinici Scientifici Maugeri IRCCS, Istituti Clinici Scientifici Maugeri IRCCS, Agenzia Nazionale per i Servizi Sanitari Regionali - “S. Chiara” Hospital, University of Campania “Luigi Vanvitelli”, AV4 ASUR Marche, University of Turin, University of Turin, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Università degli Studi di Milano, Università degli Studi di Milano, University of Pavia, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, Queen's University, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), King’s College London - Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London - Department of Biostatistics & Health Informatics, Uniformed Services University of the Health Sciences - Department of Anatomy, Physiology and Genetics, Government of the United States of America - National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Neurological Disorders and Stroke - Neurodegenerative Diseases Research Unit, King’s College London - Department of Basic and Clinical Neuroscience, Utrecht University - Department of Neurology, Trinity College (Dublin), Trinity College (Dublin) - Academic Unit of Neurology, University of Milan, University of Padova, University of Piemonte Orientale, UK-Dementia Research Institute at University College London, University of Edinburgh, University of Milan - IRCCS Istituto Auxologico Italiano, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, National Institute of Neurological Disorders and Stroke - DIR Bioinformatics Section, Government of the United States of America - National Cancer Institute, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, University of Pisa, University of Milan, Koc University, Utrecht University - Department of Neurology, University of Montpellier, Emory University - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, Government of the United States of America - National Institute on Aging (NIA), Barrow Neurological Institute, King’s College London - Maurice Wohl Clinical Neuroscience Institute, affiliation not provided to SSRN, Government of the United States of America - National Institute on Aging (NIA), Independent and Government of the United States of America - Neuromuscular Diseases Research Section