University of Montpellier, Central University Hospital of Liege, Hospital do Meixoeiro, - Center for Aging Brain, Memory Unit, - Center for Aging Brain, Memory Unit, Charité - Universitätsmedizin Berlin, Ulm University, Università di Bologna, Hospices Civils de Lyon, National Hospital for Neurology and Neurosurgery, University of Southern Denmark - Lillebaelt Hospital, Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), University of Gothenburg - Department of Psychiatry and Neurochemistry, Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau - Sant Pau Biomedical Research Institute (IIB Sant Pau), Mayo Clinic, University of Montpellier, University of Bordeaux, University of Sao Paulo, Federal University of Rio Grande do Sul (UFRGS/PPGA), Université Paris Cité, Universidade de Coimbra, University of Nantes - CHU Nantes, Vrije Universiteit Brussel (VUB), Santa Cruz de Tenerife Clinic, Italian National Research Center on Ageing IRCCS INRCA, State University of New York (SUNY) - SUNY Upstate Medical University, University College London - UCL Queen Square Institute of Neurology, University of Turin, Istanbul University, Hospices Civils de Lyon, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Istanbul University, Washington University in St. Louis - Department of Radiology, University of Angers - CHU Angers, University Hospital Nuestra Señora de Candelaria (UHNSC), Reference Laboratory of Catalonia, University Hospital Zurich, University of Turin, Lyon Neuroscience Research Centre, Niigata University, University College London, Medical University of Graz, University of Basel - University Hospital Basel, Charité - Universitätsmedizin Berlin, University Hospital Erlangen, University of Angers - CHU Angers, Aristotle University of Thessaloniki, Catholic University of Milan, Assistance Publique-Hôpitaux de Paris, Medical University of Bialystok, Hospital del Mar, University of Padova, Medical University of Bialystok, Université de Toulouse - CHU de Toulouse, Hôpital Lariboisière, Università Vita-Salute San Raffaele - San Raffaele Hospital, University of Perugia, University of Perugia, Cruces University Hospital - Biocruces Bizkaia Health Research Institute, KU Leuven - Laboratory for Molecular Neurobiomarker Research, CHU Rouen, Universidad de Valencia, University of Lille - CHU Lille, University of Naples Federico II, University of Naples Federico II, Ulm University, University of Athens, National and Kapodistrian University of Athens, LaborBerlin, VU University Amsterdam, University of British Columbia (UBC) - Djavad Mowafaghian Centre for Brain Health, University of Gothenburg, University of Amsterdam - Amsterdam Neuroscience and University of Montpellier

Government of the United States of America - Neuromuscular Diseases Research Section, University of Sheffield, Government of the United States of America - Neuromuscular Diseases Research Section, University of Sheffield, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, National Institutes of Health, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, Government of the United States of America - National Institute on Aging (NIA), National Institute on Aging (NIA) - Computational Biology Group, King’s College London, National Institute on Aging - Neuromuscular Diseases Research Section, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Milan - IRCCS Istituto Auxologico Italiano, University of Piemonte Orientale, Utrecht University - University Medical Center (Utrecht), Utrecht University - Department of Neurology, Koc University, Koc University, National Institutes of Health, Government of the United States of America - National Institute on Aging (NIA), University of Turin, University of Milan, King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Milan - IRCCS Istituto Auxologico Italiano, University of Milan, University of Milan - IRCCS Istituto Auxologico Italiano, University of Piemonte Orientale, University Medical Center Utrecht - Department of Neurology, King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Padova, University of Brescia, University of Brescia, University of Brescia - Neurology Unit, IRCCS Mondino Foundation Pavia, Sapienza University of Rome, University of Ferrara, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, Università di Modena e Reggio Emilia, Istituti Clinici Scientifici Maugeri IRCCS, Istituti Clinici Scientifici Maugeri IRCCS, Agenzia Nazionale per i Servizi Sanitari Regionali - “S. Chiara” Hospital, University of Campania “Luigi Vanvitelli”, AV4 ASUR Marche, University of Turin, University of Turin, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Università degli Studi di Milano, Università degli Studi di Milano, University of Pavia, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, Queen's University, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), King’s College London - Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London - Department of Biostatistics & Health Informatics, Uniformed Services University of the Health Sciences - Department of Anatomy, Physiology and Genetics, Government of the United States of America - National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Neurological Disorders and Stroke - Neurodegenerative Diseases Research Unit, King’s College London - Department of Basic and Clinical Neuroscience, Utrecht University - Department of Neurology, Trinity College (Dublin), Trinity College (Dublin) - Academic Unit of Neurology, University of Milan, University of Padova, University of Piemonte Orientale, UK-Dementia Research Institute at University College London, University of Edinburgh, University of Milan - IRCCS Istituto Auxologico Italiano, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, National Institute of Neurological Disorders and Stroke - DIR Bioinformatics Section, Government of the United States of America - National Cancer Institute, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, University of Pisa, University of Milan, Koc University, Utrecht University - Department of Neurology, University of Montpellier, Emory University - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, Government of the United States of America - National Institute on Aging (NIA), Government of the United States of America - National Institute on Aging (NIA), King’s College London - Maurice Wohl Clinical Neuroscience Institute, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), Government of the United States of America - National Institute on Aging (NIA) and Government of the United States of America - Neuromuscular Diseases Research Section

National Institutes of Health, University of Sheffield, Government of the United States of America - Neuromuscular Diseases Research Section, University of Sheffield, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, National Institutes of Health, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, Government of the United States of America - National Institute on Aging (NIA), National Institute on Aging (NIA) - Computational Biology Group, King’s College London, National Institute on Aging - Neuromuscular Diseases Research Section, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Milan - IRCCS Istituto Auxologico Italiano, University of Piemonte Orientale, Utrecht University - University Medical Center (Utrecht), Utrecht University - Department of Neurology, Koc University, Koc University, National Institutes of Health, Government of the United States of America - National Institute on Aging (NIA), University of Turin, University of Milan, Utrecht University - University Medical Center (Utrecht), King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Milan - IRCCS Istituto Auxologico Italiano, University of Milan, University of Milan - IRCCS Istituto Auxologico Italiano, University of Piemonte Orientale, University Medical Center Utrecht - Department of Neurology, King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Padova, University of Brescia, University of Brescia, University of Brescia - Neurology Unit, IRCCS Mondino Foundation Pavia, Sapienza University of Rome, University of Ferrara, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, Università di Modena e Reggio Emilia, Istituti Clinici Scientifici Maugeri IRCCS, Istituti Clinici Scientifici Maugeri IRCCS, Agenzia Nazionale per i Servizi Sanitari Regionali - “S. Chiara” Hospital, University of Campania “Luigi Vanvitelli”, AV4 ASUR Marche, University of Turin, University of Turin, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Università degli Studi di Milano, Università degli Studi di Milano, University of Pavia, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, Queen's University, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), King’s College London - Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London - Department of Biostatistics & Health Informatics, Uniformed Services University of the Health Sciences - Department of Anatomy, Physiology and Genetics, Government of the United States of America - National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Neurological Disorders and Stroke - Neurodegenerative Diseases Research Unit, King’s College London - Department of Basic and Clinical Neuroscience, Utrecht University - Department of Neurology, Trinity College (Dublin), Trinity College (Dublin) - Academic Unit of Neurology, University of Milan, University of Padova, University of Piemonte Orientale, UK-Dementia Research Institute at University College London, University of Edinburgh, University of Milan - IRCCS Istituto Auxologico Italiano, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, National Institute of Neurological Disorders and Stroke - DIR Bioinformatics Section, Government of the United States of America - National Cancer Institute, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, University of Pisa, University of Milan, Koc University, Utrecht University - Department of Neurology, University of Montpellier, Emory University - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, Government of the United States of America - National Institute on Aging (NIA), Barrow Neurological Institute, King’s College London - Maurice Wohl Clinical Neuroscience Institute, affiliation not provided to SSRN, Government of the United States of America - National Institute on Aging (NIA), Independent and Government of the United States of America - Neuromuscular Diseases Research Section