Government of the United States of America - Neuromuscular Diseases Research Section, University of Sheffield, Government of the United States of America - Neuromuscular Diseases Research Section, University of Sheffield, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, National Institutes of Health, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, Government of the United States of America - National Institute on Aging (NIA), National Institute on Aging (NIA) - Computational Biology Group, King’s College London, National Institute on Aging - Neuromuscular Diseases Research Section, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Milan - IRCCS Istituto Auxologico Italiano, University of Eastern Piedmont, Utrecht University - University Medical Center (Utrecht), Utrecht University - Department of Neurology, Koc University, Koc University, National Institutes of Health, Government of the United States of America - National Institute on Aging (NIA), University of Turin, University of Milan, King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Milan - IRCCS Istituto Auxologico Italiano, University of Milan, University of Milan - IRCCS Istituto Auxologico Italiano, University of Piemonte Orientale, University Medical Center Utrecht - Department of Neurology, King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Padova, University of Brescia, University of Brescia, University of Brescia - Neurology Unit, IRCCS Mondino Foundation Pavia, Sapienza University of Rome, University of Ferrara, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, Università di Modena e Reggio Emilia, Istituti Clinici Scientifici Maugeri IRCCS, Istituti Clinici Scientifici Maugeri IRCCS, Agenzia Nazionale per i Servizi Sanitari Regionali - “S. Chiara” Hospital, University of Campania “Luigi Vanvitelli”, AV4 ASUR Marche, University of Turin, University of Turin, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Università degli Studi di Milano, Università degli Studi di Milano, University of Pavia, University of Milan, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, Queen's University, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), King’s College London - Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London - Department of Biostatistics & Health Informatics, Uniformed Services University of the Health Sciences - Department of Anatomy, Physiology and Genetics, Government of the United States of America - National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Neurological Disorders and Stroke - Neurodegenerative Diseases Research Unit, King’s College London - Department of Basic and Clinical Neuroscience, Utrecht University - Department of Neurology, Trinity College (Dublin), Trinity College (Dublin) - Academic Unit of Neurology, University of Milan, University of Padova, University of Eastern Piedmont, UK-Dementia Research Institute at University College London, University of Edinburgh, University of Milan - IRCCS Istituto Auxologico Italiano, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, National Institute of Neurological Disorders and Stroke - DIR Bioinformatics Section, Government of the United States of America - National Cancer Institute, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, University of Pisa, University of Milan, Koc University, Utrecht University - Department of Neurology, University of Montpellier, Emory University - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, Government of the United States of America - National Institute on Aging (NIA), Government of the United States of America - National Institute on Aging (NIA), King’s College London - Maurice Wohl Clinical Neuroscience Institute, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), Government of the United States of America - National Institute on Aging (NIA) and Government of the United States of America - Neuromuscular Diseases Research Section

National Institute on Aging - Neuromuscular Diseases Research Section, National Institutes of Health - Neuromuscular Diseases Research Section, National Institutes of Health - Computational Biology Core, Columbia University - Department of Pathology and Cell Biology, Boston University - Chronic Traumatic Encephalopathy Center, National Institutes of Health - Neuromuscular Diseases Research Section, National Institute of Neurological Disorders and Stroke - Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke - Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke - Neurodegenerative Diseases Research Unit, Queen Mary University of London - Clinical Pharmacology, Queen Mary University of London - Clinical Pharmacology, University of Massachusetts Worcester - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - Division of Neurology V and Neuropathology, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - Division of Neurology V and Neuropathology, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - Scientific Directorate, Lund University - Division of Clinical Sciences Helsingborg, Lund University - Division of Clinical Sciences Helsingborg, Lund University - Clinical Memory Research Unit, Independent, Independent, Independent, Independent, Independent, Independent, Independent, Independent, University of Cambridge - MRC Cognition and Brain Sciences Unit, IRCCS Centro San Giovanni di Dio Fatebenefratelli - Molecular Markers Laboratory, IRCCS Centro San Giovanni di Dio Fatebenefratelli - Molecular Markers Laboratory, IRCCS Centro San Giovanni di Dio Fatebenefratelli - Molecular Markers Laboratory, University College London - Department of Molecular Neuroscience, Uniformed Services University of the Health Sciences - Department of Anatomy, Physiology and Genetics, Emory University - Department of Neurology, Government of the United States of America - Center for Alzheimer's and Related Dementias (CARD), University of Massachusetts Worcester - Department of Neurology, Mayo Clinic - Department of Neuroscience, University College London - Department of Molecular Neuroscience, Scripps Translational Science Institute, National Institute on Aging - Translational Gerontology Branch, Government of the United States of America - Translational Gerontology Branch, National Institute on Aging (NIA) - Laboratory of Behavioral Neuroscience, The University of Manchester - Faculty of Human and Medical Sciences, Boston University - Department of Neurology, VA Boston Healthcare System - Department of Neurology, University College London - Department of Neurodegenerative Disease, University of Pennsylvania - Department of Pathology and Laboratory Medicine, Columbia University - Department of Pathology and Cell Biology, Columbia University - Department of Neurology, University College London - Department of Clinical and Movement Neurosciences, University College London - Department of Molecular Neuroscience, University of Massachusetts Worcester - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, National Institute on Aging (NIA) - Computational Biology Group, Uniformed Services University of the Health Sciences - Department of Anatomy, Physiology and Genetics, National Institute of Neurological Disorders and Stroke - Neurodegenerative Diseases Research Unit and University of Massachusetts Worcester - Department of Neurology

National Institutes of Health, University of Sheffield, Government of the United States of America - Neuromuscular Diseases Research Section, University of Sheffield, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, National Institutes of Health, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, St. Joseph's Hospital and Medical Center - Barrow Neurological Institute, Government of the United States of America - National Institute on Aging (NIA), National Institute on Aging (NIA) - Computational Biology Group, King’s College London, National Institute on Aging - Neuromuscular Diseases Research Section, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Milan - IRCCS Istituto Auxologico Italiano, University of Eastern Piedmont, Utrecht University - University Medical Center (Utrecht), Utrecht University - Department of Neurology, Koc University, Koc University, National Institutes of Health, Government of the United States of America - National Institute on Aging (NIA), University of Turin, University of Milan, Utrecht University - University Medical Center (Utrecht), King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Milan - IRCCS Istituto Auxologico Italiano, University of Milan, University of Milan - IRCCS Istituto Auxologico Italiano, University of Piemonte Orientale, University Medical Center Utrecht - Department of Neurology, King’s College London - Department of Basic and Clinical Neuroscience, King’s College London, University of Padova, University of Brescia, University of Brescia, University of Brescia - Neurology Unit, IRCCS Mondino Foundation Pavia, Sapienza University of Rome, University of Ferrara, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, University of Turin, Università di Modena e Reggio Emilia, Istituti Clinici Scientifici Maugeri IRCCS, Istituti Clinici Scientifici Maugeri IRCCS, Agenzia Nazionale per i Servizi Sanitari Regionali - “S. Chiara” Hospital, University of Campania “Luigi Vanvitelli”, AV4 ASUR Marche, University of Turin, University of Turin, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Università degli Studi di Milano, Università degli Studi di Milano, University of Pavia, University of Milan, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, University of Nottingham - NIHR Biomedical Research Centre, Queen's University, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), King’s College London - Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London - Department of Biostatistics & Health Informatics, Uniformed Services University of the Health Sciences - Department of Anatomy, Physiology and Genetics, Government of the United States of America - National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Neurological Disorders and Stroke - Neurodegenerative Diseases Research Unit, King’s College London - Department of Basic and Clinical Neuroscience, Utrecht University - Department of Neurology, Trinity College (Dublin), Trinity College (Dublin) - Academic Unit of Neurology, University of Milan, University of Padova, University of Eastern Piedmont, UK-Dementia Research Institute at University College London, University of Edinburgh, University of Milan - IRCCS Istituto Auxologico Italiano, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, National Institute of Neurological Disorders and Stroke - DIR Bioinformatics Section, Government of the United States of America - National Cancer Institute, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, National Institutes of Health, Bethesda - National Institute of Mental Health, University of Pisa, University of Milan, Koc University, Utrecht University - Department of Neurology, University of Montpellier, Emory University - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, Government of the United States of America - National Institute on Aging (NIA), Barrow Neurological Institute, King’s College London - Maurice Wohl Clinical Neuroscience Institute, affiliation not provided to SSRN, Government of the United States of America - National Institute on Aging (NIA), Independent and Government of the United States of America - Neuromuscular Diseases Research Section