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Arthur Christopoulos

Monash University - Drug Discovery Biology

Parkville, VIC 3052

Australia

  • Monash University - Drug Discovery Biology

SCHOLARLY PAPERS

5

DOWNLOADS

372

TOTAL CITATIONS

0

Scholarly Papers (5)

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1.

Isoquinoline Small Molecule Ligands are Agonists and Probe-Dependent Allosteric Modulators of the Glucagon Subfamily of Gpcrs

Number of pages: 28 Posted: 22 May 2024
Elita Yuliantie, Phuc NH Trinh, Caroline Hick, Rebecca Ebenhoch, Herbert Nar, Dietmar Weichert, Arthur Christopoulos, Patrick M. Sexton and Denise Wootten
Monash University - Monash Institute of Pharmaceutical Sciences, Monash University - Monash Institute of Pharmaceutical Sciences, Monash University - Monash Institute of Pharmaceutical Sciences, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology and Monash University - Drug Discovery Biology
Downloads 111 (635,507)

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GIPR, GLP1R, GCGR, CTR, class B1 GPCRs, allosteric modulation

2.

Structural and Dynamic Mechanisms of Allostery at the M4 Muscarinic Acetylcholine Receptor

Number of pages: 79 Posted: 14 Feb 2022
Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I. Mobbs, Matthew J. Belousoff, Apurba Bhattarai, Wessel A.C. Burger, Geoff Thompson, Mahmuda Yeasmin, Vindhya Nawaratne, Katie Leach, Emma T. van der Westhuizen, Elham Khajehali, Yi-Lynn Liang, Alisa Glukhova, Denise Wootten, Craig W. Lindsley, Andrew Tobin, Patrick M. Sexton, Radostin Danev, Celine Valant, Yinglong Miao, Arthur Christopoulos and David Thal
Monash University - Drug Discovery Biology, University of Kansas - Center for Computational Biology and Department of Molecular Biosciences, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology, University of Kansas - Center for Computational Biology and Department of Molecular Biosciences, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology, Vanderbilt University - Department of Pharmacology, University of Glasgow - The Centre for Translational Pharmacology, Monash University - Drug Discovery Biology, University of Tokyo - Graduate School of Medicine, Monash University - Drug Discovery Biology, University of Kansas - Center for Computational Biology and Department of Molecular Biosciences, Monash University - Drug Discovery Biology and Monash University - Drug Discovery Biology
Downloads 111 (635,507)

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G protein coupled-receptor, M4 muscarinic acetylcholine receptor, allostery, cryoelectron microscopy, molecular dynamics, pharmacology, drug discovery

3.

From Structure to Clinic: Discovery of A M1 Muscarinic Acetylcholine Receptor Agonist for the Treatment of Memory Loss in Alzheimer's Disease

Number of pages: 113 Posted: 29 Jul 2020
Alastair J. H. Brown, Sophie J. Bradley, Giles A. Brown, Kirstie A. Bennett, Jason Brown, Julie E. Cansfield, David M. Cross, João M. Dias, James C. Errey, Edward Hurrell, Jan Liptrot, Colin Molloy, Pradeep J. Nathan, Krzysztof Okrasa, Greg Osbourne, Jayesh C. Patel, Mark Pickworth, Nathan Robertson, Shahram Shahabi, Christoffer Bundgaard, Keith Phillips, Lisa M. Broad, Anushka V. Goonawardena, Stephen R. Morairty, Michael Browning, Francesca Perini, Gerard R. Dawson, John F. W. Deakin, Robert T. Smith, Patrick M. Sexton, Julie Warneck, Mary Vinson, Tim Tasker, Benjamin G. Tehan, Barry Teobald, Arthur Christopoulos, Christopher J. Langmead, Ali Jazayeri, Robert M. Cooke, Fiona H. Marshall, Prakash Rucktooa, Miles S. Congreve, Malcolm Weir and Andrew Tobin
Sosei Heptares, University of Glasgow, Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares, University of Glasgow, Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares, OXGENE Biotechnology, Eli Lilly & Co - Neuroscience Discovery, Eli Lilly & Co - Neuroscience Discovery, Eli Lilly and Company, Ltd - Research and Development, Eli Lilly & Co - Neuroscience Discovery, Institute of Scientific Research and High Technology Services (INDICASAT AIP) - Center for Neuroscience, Institute of Scientific Research and High Technology Services (INDICASAT AIP) - Center for Neuroscience, University of Oxford, Duke-NUS Medical School, University of Oxford - Department of Psychiatry, The University of Manchester, Sosei Heptares, Monash University - Drug Discovery Biology, Protogenia Consulting, Ltd., Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares, Monash University - Drug Discovery Biology, Monash University - Monash Institute of Pharmaceutical Sciences, Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares, Sosei Heptares and University of Glasgow - The Centre for Translational Pharmacology
Downloads 71 (867,774)

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4.

Ligand-Directed Biased Agonism at Human Histamine H3 Receptor Isoforms Across Gαi/O- and Β-Arrestin2-Mediated Pathways

Number of pages: 74 Posted: 26 Oct 2023
Sabrina Nalini Rahman, Faissal Imhaouran, Rob Leurs, Arthur Christopoulos, Celine Valant and Christopher J. Langmead
Monash University - Monash Institute of Pharmaceutical Sciences, VU University Amsterdam, VU University Amsterdam, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology and Monash University - Monash Institute of Pharmaceutical Sciences
Downloads 49 (1,074,648)

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G protein-coupled receptors (GPCRs)histamine H3 receptor (H3R)receptor isoformsbiased agonismligand biasneuromodulation

5.

Design, Synthesis and Evaluation of Novel 2-Phenyl-3-(1H-Pyrazol-4-yl)Pyridine Positive Allosteric Modulators for the M4 mAChR

Number of pages: 59 Posted: 04 May 2023
Manuela Jörg, Emma T. van der Westhuizen, Yao Lu, K. H. Christopher Choy, David M. Shackleford, Elham Khajehali, Andrew Tobin, David Thal, Ben Capuano, Arthur Christopoulos, Celine Valant and Peter Scammells
Monash University - Monash Institute of Pharmaceutical Sciences, Monash University - Drug Discovery Biology, Monash University - Monash Institute of Pharmaceutical Sciences, Monash University - Monash Institute of Pharmaceutical Sciences, Monash University - Monash Institute of Pharmaceutical Sciences, Monash University - Monash Institute of Pharmaceutical Sciences, University of Glasgow - The Centre for Translational Pharmacology, Monash University - Drug Discovery Biology, Monash University - Monash Institute of Pharmaceutical Sciences, Monash University - Drug Discovery Biology, Monash University - Drug Discovery Biology and Monash University - Monash Institute of Pharmaceutical Sciences
Downloads 30 (1,318,317)

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acetylcholine, allosteric ligands, M4 muscarinic acetylcholine receptor, positive allosteric modulators, xanomeline