Great Ormond Street Hospital for Children NHS Foundation Trust - Paediatric Intensive Care Unit, Intensive Care National Audit and Research Centre, Great Ormond Street Hospital for Children NHS Foundation Trust - Paediatric Intensive Care Unit, Intensive Care National Audit and Research Centre, Intensive Care National Audit and Research Centre, Intensive Care National Audit and Research Centre, Great Ormond Street Hospital for Children NHS Foundation Trust - Paediatric Intensive Care Unit, NHS Foundation Trust - Great North Children’s Hospital, Intensive Care National Audit and Research Centre, University of Leicester - Department of Population Health Sciences, University of Exeter, Intensive Care National Audit and Research Centre, Great Ormond Street Hospital for Children NHS Foundation Trust, Intensive Care National Audit and Research Centre, Evelina Children's Hospital - Paediatric Intensive Care Unit (PICU), University of Southampton - University Hospital Southampton NHS Foundation Trust, Intensive Care National Audit and Research Centre, Great Ormond Street Hospital for Children NHS Foundation Trust, London School of Hygiene & Tropical Medicine - Department of Public Health and Policy, Kilifi County Hospital, Intensive Care National Audit and Research Centre, Intensive Care National Audit and Research Centre and Independent

University of Oxford, Imperial College London, Tel Aviv University, Imperial College London - Section of Paediatric Infectious Disease, Imperial College London, Imperial College London, Imperial College London, University of Cambridge, Government of the United Kingdom - Barts Health NHS Trust, Wellcome Sanger Institute, University of Oxford - Wellcome Centre for Human Genetics, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), Imperial College London - Section of Paediatric Infectious Disease, Imperial College London - Section of Paediatric Infectious Disease, St Mary’s Hospital, Great Ormond Street Hospital for Children NHS Foundation Trust - Paediatric Intensive Care Unit and Great Ormond Street Hospital for Children NHS Foundation Trust