Imperial College London, Imperial College London - Section of Paediatric Infectious Disease, Imperial College London, Imperial College London, Imperial College London, Imperial College London, University College London, Imperial College London, Imperial College London - Imperial College Healthcare NHS Trust, Department of Infectious Disease, Imperial College London, Imperial College London - Institute of Reproductive and Developmental Biology, Imperial College London, Imperial College London, Imperial College London, Department of Infectious Disease, Imperial College London, Imperial College London - Section of Paediatric Infectious Disease, Imperial College London, Imperial College London, University College London - Institute for Health Informatics, University of Oxford - Wellcome Centre for Human Genetics, Department of Infectious Disease, Imperial College London, Imperial College London - Department of Infectious Disease, University College London - Division of Infection and Immunity and Imperial College London - Department of Medicine

University of Oxford, Imperial College London, Tel Aviv University, Imperial College London - Section of Paediatric Infectious Disease, Imperial College London, Imperial College London, Imperial College London, University of Cambridge, Government of the United Kingdom - Barts Health NHS Trust, Wellcome Sanger Institute, University of Oxford - Wellcome Centre for Human Genetics, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), Imperial College London - Section of Paediatric Infectious Disease, Imperial College London - Section of Paediatric Infectious Disease, St Mary’s Hospital, Great Ormond Street Hospital for Children NHS Foundation Trust - Paediatric Intensive Care Unit and Great Ormond Street Hospital for Children NHS Foundation Trust

Imperial College London, affiliation not provided to SSRN, affiliation not provided to SSRN, Universidade de Santiago de Compostela - Genetics, Vaccines, Infections and Paediatrics Research group (GENVIP), affiliation not provided to SSRN, Imperial College London - Section of Paediatric Infectious Disease, Imperial College London, Imperial College London - Department of Epidemiology and Biostatistics, affiliation not provided to SSRN, Imperial College London, University of Liverpool, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, London School of Hygiene & Tropical Medicine - Medical Research Council Unit The Gambia, Imperial College London, affiliation not provided to SSRN, Erasmus University Rotterdam (EUR) - Department of Paediatric Infectious Diseases and Immunology, affiliation not provided to SSRN, Bern University Hospital, University of Bern, Imperial College London, Radboud University Nijmegen - Section of Paediatric Infectious Diseases, NHS Foundation Trust - Department of Paediatric Immunology, Infectious Diseases & Allergy, Royal Alexandra Hospital, University of Amsterdam - Department of Pediatric Immunology, Rheumatology and Infectious Disease, affiliation not provided to SSRN, Erasmus University Rotterdam (EUR) - Department of General Paediatrics, University of Oxford - Oxford Vaccine Group, affiliation not provided to SSRN, University of Oxford - Oxford Vaccine Group, University of Zurich, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Ludwig Maximilian University of Munich (LMU) - Division of Paediatric Infectious Diseases, London School of Hygiene & Tropical Medicine - Department of Clinical Research, affiliation not provided to SSRN, Medical University of Graz - Department of General Paediatrics, Imperial College London, University of Liverpool - Institute of Infection, Veterinary and Ecological Sciences, Imperial College London - Section of Paediatric Infectious Disease, Universidad Complutense de Madrid (UCM), affiliation not provided to SSRN, Imperial College London - Section of Paediatric Infectious Disease, Imperial College London - Section of Paediatric Infectious Disease and affiliation not provided to SSRN