Mike A. Nalls

National Institutes of Health - Molecular Genetics Section

Bethseda, MD 20892

United States

SCHOLARLY PAPERS

3

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Scholarly Papers (3)

1.

Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene

Number of pages: 74 Posted: 06 Aug 2018
Aude Nicolas, Kevin P. Kenna, Alan E. Renton, Nicola Ticozzi, Faraz Faghri, Ruth Chia, Janice A. Dominov, Brendan J. Kenna, Mike A. Nalls, Pamela Keagle, Alberto M. Rivera, Wouter van Rheenen, Natalie A. Murphy, Joke J.F.A. van Vugt, Joshua T. Geiger, Rick A. Van der Spek, Hannah A. Pliner, Bradley N. Smith, Giuseppe Marangi, Simon D. Topp, Yevgeniya Abramzon, Athina Soragia Gkazi, John D. Eicher, Aoife Kenna, ITALSGEN Consortium, Gabriele Mora, Andrea Calvo, Letizia Mazzini, Nilo Riva, Jessica Mandrioli, Claudia Caponnetto, Stefania Battistini, Paolo Volanti, Vincenzo La Bella, Francesca L. Conforti, Giuseppe Borghero, Sonia Messina, Isabella L. Simone, Francesca Trojsi, Fabrizio Salvi, Francesco O. Logullo, Sandra D’Alfonso, Lucia Corrado, Margherita Capasso, Luigi Ferrucci, Genomic Translation for ALS Care (GTAC) Consortium, Cristiane de Araujo Martins Moreno, Sitharthan Kamalakaran, David B. Goldstein, The ALS Sequencing Consortium, Aaron D. Gitler, Tim Harris, Richard M. Myers, NYGC ALS Consortium, Hemali Phatnani, Rajeeva Lochan Musunuri, Uday Shankar Evani, Avinash Abhyankar, Michael Charles Zody, Answer ALS Foundation, Julia Kaye, Steven Finkbeiner, Stacia Wyman, Alex Lenail, Leandro Lima, Ernest Fraenkel, Clive N. Svendsen, Leslie M. Thompson, Jennifer E. Van Eyk, James D. Berry, Timothy M. Miller, Stephen J. Kolb, Merit Cudkowicz, Emily Baxi, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, Michael Benatar, J. Paul Taylor, Evadnie Rampersaud, Gang Wu, Joanne Wuu, SLAGEN Consortium, Giuseppe Lauria, Federico Verde, Isabella Fogh, Cinzia Tiloca, Giacomo P. Comi, Gianni Sorarù, Cristina Cereda, French ALS Consortium, Philippe Corcia, Hannu Laaksovirta, Liisa Myllykangas, Lilja Jansson, Miko Valori, John Ealing, Hesham Hamdallah, Sara Rollinson, Stuart Pickering-Brown, Richard W. Orrell, Katie C. Sidle, Andrea Malaspina, John Hardy, Andrew B. Singleton, Janel O. Johnson, Sampath Arepalli, Peter C. Sapp, Diane McKenna-Yasek, Meraida Polak, Seneshaw Asress, Safa Al-Sarraj, Andrew King, Claire Troakes, Caroline Vance, Jacqueline de Belleroche, Frank Baas, Anneloor LMA ten Asbroek, José Luis Muñoz-Blanco, Dena G. Hernandez, Jinhui Ding, J. Raphael Gibbs, Sonja W. Scholz, Mary Kay Floeter, Roy H. Campbell, Francesco Landi, Stefan M. Pulst, John M. Ravits, Daniel J. L. MacGowan, Janine Kirby, Erik Pioro, Roger Pamphlett, James Broach, Glenn Gerhard, Travis L. Dunckley, Christopher B. Brady, Neil W. Kowall, Juan Troncoso, Isabelle Le Ber, Kevin Mouzat, Serge Lumbroso, Terry D. Heiman-Patterson, Freya Kamel, Ludo Van Den Bosch, Robert H. Baloh, Tim M. Strom, Thomas Meitinger, Aleksey Shatunov, Kristel R. Van Eijk, Mamede de Carvalho, Maarten Kooyman, Bas Middelkoop, Matthieu Moisse, Russell L. McLaughlin, Michael A. Van Es, Markus Weber, Kevin B. Boylan, Marka Van Blitterswijk, Rosa Rademakers, Karen E. Morrison, A. Nazli Basak, Jesús S. Mora, Vivian E. Drory, Pamela J. Shaw, Martin R. Turner, Kevin Talbot, Orla Hardiman, Kelly L. Williams, Jennifer A. Fifita, Garth A. Nicholson, Ian P. Blair, Guy A. Rouleau, Jesús Esteban-Pérez, Alberto García-Redondo, Ammar Al-Chalabi, Project MinE ALS Sequencing Consortium, Ekaterina Rogaeva, Lorne Zinman, Lyle Ostrow, Nicholas J. Maragakis, Jeffrey D. Rothstein, Zachary Simmons, Johnathan Cooper-Knock, Alexis Brice, Stephen A. Goutman, Eva L. Feldman, Summer B. Gibson, Franco Taroni, Antonia Ratti, Cinzia Gellera, Philip Van Damme, Wim Robberecht, Pietro Fratta, Mario Sabatelli, Christian Lunetta, Albert C. Ludolph, Peter M. Andersen, Jochen H. Weishaupt, William Camu, John Q. Trojanowski, Vivianna M. Van Deerlin, Robert H. Brown, Leonard H. van den Berg, Jan H. Veldink, Matthew B. Harms, Jonathan D. Glass, David J. Stone, Pentti Tienari, Vincenzo Silani, Adriano Chiò, Christopher E. Shaw, Bryan J. Traynor and John E. Landers
Government of the United States of America - Neuromuscular Diseases Research Section, University of Massachusetts Worcester - Department of Neurology, Icahn School of Medicine at Mount Sinai - Nash Department of Neuroscience, University of Milan - Department of Neurology and Laboratory of Neuroscience, National Institutes of Health - Molecular Genetics Section, National Institutes of Health - Neuromuscular Diseases Research Section, University of Massachusetts Worcester - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, National Institutes of Health - Molecular Genetics Section, University of Massachusetts Worcester - Department of Neurology, Government of the United States of America - Neuromuscular Diseases Research Section, Utrecht University - Department of Neurology, Government of the United States of America - Neuromuscular Diseases Research Section, Utrecht University - Department of Neurology, Government of the United States of America - Neurodegenerative Diseases Research Unit, Utrecht University - Department of Neurology, National Institutes of Health - Neurodegenerative Diseases Research Unit, United Kingdom Dementia Research Institute Centre, Government of the United States of America - Neuromuscular Diseases Research Section, United Kingdom Dementia Research Institute Centre, National Institutes of Health - Neuromuscular Diseases Research Section, United Kingdom Dementia Research Institute Centre, Merck & Co., Inc. - Genetics and Pharmacogenomics, University of Massachusetts Worcester - Department of Neurology, affiliation not provided to SSRN, Azienda Ospedaliera Universitaria Maggiore della Carità - ALS Center, University of Turin - Department of Neurosciences, Azienda Ospedaliera Universitaria Maggiore della Carità - ALS Center, Università Vita-Salute San Raffaele - Department of Neurology, Azienda Ospedaliero Universitaria di Modena - Department of Neuroscience, Institute of Hospitalization and Care with a Scientific Character (IRCCS) - Ophthalmology, Genetics, Rehabilitation, Maternal and Child Health, University of Siena - Department of Medical, Surgical and Neurological Sciences, Salvatore Maugeri Foundation IRCCS - ALS Center, University of Palermo - ALS Clinical Research Center, University of Palermo - ALS Clinical Research Center, Universita di Cagliari - Department of Neurology, University of Messina - Department of Clinical and Experimental Medicine, Università degli Studi di Bari “Aldo Moro” (UNIBA) - Department of Basic Medical Sciences, Neurosciences and Sense Organs, Università degli Studi della Campania - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB) - Il Bene Center for Immunological and Rare Neurological Diseases, Università Politecnica delle Marche - Neurological Clinic, University of Eastern Piedmont - Department of Health Sciences, University of Eastern Piedmont - Department of Health Sciences, 'Gabriele d'Annunzio' University of Chieti-Pescara - Department of Neurology, Government of the United States of America - Longitudinal Studies Section, affiliation not provided to SSRN, Columbia University Medical Center, Department of Neurology, Columbia University Medical Center, Department of Neurology, Columbia University - Institute for Genomic Medicine, affiliation not provided to SSRN, Stanford University - Department of Genetics, Bioverativ, HudsonAlpha Institute for Biotechnology, affiliation not provided to SSRN, New York Genome Center - Center for Genomics of Neurodegenerative Diseases (CGND), New York Genome Center - Computational Biology, New York Genome Center - Computational Biology, New York Genome Center - Computational Biology, New York Genome Center - Computational Biology, affiliation not provided to SSRN, University of California, San Francisco (UCSF) - Gladstone Institute of Neurological Disease, University of California, San Francisco (UCSF) - Gladstone Institute of Neurological Disease, University of California, San Francisco (UCSF) - Gladstone Institutes, Massachusetts Institute of Technology (MIT) - Department of Biological Engineering, University of California, San Francisco (UCSF) - Gladstone Institute of Neurological Disease, Massachusetts Institute of Technology (MIT) - Department of Biological Engineering, Cedars-Sinai Medical Center, Board of Governors Regenerative Medicine Institute, University of California, Irvine - Department of Neurobiology and Behavior, Cedars-Sinai Medical Center, Department of Medicine, Harvard University - Department of Neurology, Washington University in St. Louis - Department of Neurology, Ohio State University (OSU) - Department of Neurology, Harvard University - Department of Neurology, Johns Hopkins University - Department of Neurology and Neurosurgery, affiliation not provided to SSRN, University of Miami - Department of Neurology, Howard Hughes Medical Institute (HHMI) - Chevy Chase, St Jude Children’s Research Hospital - Department of Computational Biology, St Jude Children’s Research Hospital - Department of Computational Biology, University of Miami - Department of Neurology, Independent, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - 3rd Neurology Unit, University of Milan - Department of Neurology, University of London - Maurice Wohl Clinical Neuroscience Institute, University of Milan - Department of Neurology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Neurology Unit, University of Padova - Department of Neurosciences, IRCCS ‘C. Mondino’ National Institute of Neurology Foundation - Experimental Neurobiology Laboratory, affiliation not provided to SSRN, François Rabelais University - ALS Center, University of Helsinki - Molecular Neurology Programme, University of Helsinki - Department of Pathology, University of Helsinki - Molecular Neurology Programme, University of Helsinki - Department of Neurology, Government of the United Kingdom - Department of Neurology, Government of the United Kingdom - Department of Neurology, University of Manchester - Faculty of Human and Medical Sciences, University of Manchester - Faculty of Human and Medical Sciences, University College London - Department of Clinical Neuroscience, University College London - Department of Molecular Neuroscience, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, Wingate Institute of Neurogastroenterology, Centre for Neuroscience and Trauma, University College London - Department of Molecular Neuroscience, Government of the United States of America - Laboratory of Neurogenetics, Government of the United States of America - Neuromuscular Diseases Research Section, Government of the United States of America - Genomics Technology Group, University of Massachusetts Worcester - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, Emory University - Department of Neurology, Emory University - Department of Neurology, United Kingdom Dementia Research Institute Centre, United Kingdom Dementia Research Institute Centre, United Kingdom Dementia Research Institute Centre, United Kingdom Dementia Research Institute Centre, Imperial College London - Division of Brain Sciences, University of Amsterdam - Department of Genome analysis and Neurogenetics, University of Amsterdam - Department of Neurogenetics and Neurology, Gregorio Marañón Hospital - Unidad de ELA, Government of the United States of America - Genomics Technology Group, National Institutes of Health - Computational Biology Core, National Institutes of Health - Computational Biology Core, National Institutes of Health - Neurodegenerative Diseases Research Unit, Government of the United States of America - Motor Neuron Disorders Unit, University of Illinois at Urbana-Champaign - Department of Computer Science, Catholic University of Rome - Center for Geriatric Medicine, University of Utah - Department of Neurology, University of California, San Diego (UCSD) - Department of Neurosciences, Mount Sinai Health System - Mount Sinai Beth Israel Hospital, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), Cleveland Clinic - Department of Neurology, The University of Sydney - Discipline of Pathology, Pennsylvania State University - Department of Biochemistry, Pennsylvania State University - Department of Pathology, Pennsylvania State University - Department of Pathology, Government of the United States of America - Research and Development Service, Government of the United States of America - Neurology Service, Johns Hopkins University - Department of Pathology, Université Paris VI Pierre et Marie Curie - Hôpitaux de Paris (AP-HP) - Hôpital Pitié-Salpêtrière, UNIMES - Université de Nîmes - Department of Biochemistry, UNIMES - Université de Nîmes - Department of Biochemistry, Temple University - Department of Neurology, Government of the United States of America - Epidemiology Branch, KU Leuven - Division of Experimental Neurology, Cedars Sinai Medical Center - Department of Neurology, Helmholtz Association of German Research Centres - Institute of Human Genetics, Technische Universität München (TUM) - Institute of Human Genetics, University of London - Maurice Wohl Clinical Neuroscience Institute, Utrecht University - Department of Neurology, University of Lisbon - Institute of Physiology, SURFsara, Utrecht University - Department of Neurology, KU Leuven - Division of Experimental Neurology, Trinity College (Dublin) - Population Genetics Laboratory, Utrecht University - Department of Neurology, Kantonsspital St. Gallen - Neuromuscular Diseases Unit/ALS Clinic, Mayo Clinic - Florida - Department of Neurology, Mayo Clinic - Florida - Department of Neuroscience, Mayo Clinic - Florida - Department of Neuroscience, University of Southampton - Faculty of Medicine, Health and Life Sciences, Bogazici University - Suna and Inan K?rac Foundation, Hospital San Rafael - ALS Unit/Neurology, Tel Aviv Sourasky Medical Centre - Department of Neurology, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), University of Oxford - Nuffield Department of Clinical Neurosciences, University of Oxford - Nuffield Department of Clinical Neurosciences, Trinity College (Dublin) - Academic Unit of Neurology, Macquarie University - Centre for MND Research, Macquarie University - Centre for MND Research, Macquarie University - Centre for MND Research, Macquarie University - Centre for MND Research, McGill University - Montreal Neurological Institute and Hospital, Gregorio Marañón Hospital - Unidad de ELA, Gregorio Marañón Hospital - Unidad de ELA, University of London - Maurice Wohl Clinical Neuroscience Institute, affiliation not provided to SSRN, University of Toronto - Tanz Centre for Research of Neurodegenerative Diseases, University of Toronto - Division of Neurology, Johns Hopkins University - Department of Neurology and Neurosurgery, Johns Hopkins University - Department of Neurology and Neurosurgery, Johns Hopkins University - Brain Science Institute, Pennsylvania State University - Department of Neurology, University of Sheffield - Sheffield Institute for Translational Neuroscience (SITraN), Université Paris VI Pierre et Marie Curie - Hôpitaux de Paris (AP-HP) - Hôpital Pitié-Salpêtrière, University of Michigan at Ann Arbor - Department of Neurology, University of Michigan at Ann Arbor - Department of Neurology, University of Utah - Department of Neurology, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - Unit of Genetics of Neurodegenerative and Metabolic Diseases, University of Milan - Department of Pathophysiology and Transplantation, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’ - Unit of Genetics of Neurodegenerative and Metabolic Diseases, KU Leuven - Laboratory of Neurobiology, KU Leuven - Laboratory of Neurobiology, University College London - Sobell Department of Motor Neuroscience and Movement Disorders, Catholic University of Rome - Institute of Neurology, Centro Clinico NeMO, Serena Foundation Onlus - Clinical Center NEMO (NEuroMuscular Omnicenter), University of Ulm - Department of Neurology, University of Umea - Department of Pharmacology and Clinical Neuroscience, University of Ulm - Department of Neurology, University of Montpellier - ALS Center, University of Pennsylvania - Department of Pathology and Lab Medicine, University of Pennsylvania - Department of Pathology and Lab Medicine, University of Massachusetts Worcester - Department of Neurology, Utrecht University - Department of Neurology, Utrecht University - Department of Neurology, Columbia University Medical Center, Department of Neurology, Emory University - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, University of Massachusetts Worcester - Department of Neurology, University of Massachusetts Worcester - Department of Neurology and University of Massachusetts Worcester - Department of Neurology
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2.

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

CELL-D-19-02838
Number of pages: 99 Posted: 01 Nov 2019
Natasha Ng, Sara M. Willems, Juan Fernandez, Rebecca S. Fine, Eleanor Wheeler, Jennifer Wessel, Hidetoshi Kitajima, Gaëlle Marenne, Jana K. Rundle, Xueling Sim, Hanieh Yeghootkar, Nicola L. Beer, Anne Raimondo, Andrei I. Tarasov, Soren K. Thomsen, Martijn van de Bunt, Shuai Wang, Sai Chen, Yuning Chen, Yii-Der Ida Chen, Hugoline G. de Haan, Niels Grarup, Ruifang Li-Gao, Tibor V. Varga, Jennifer L Asimit, Shuang Feng, Rona J. Strawbridge, Erica L. Kleinbrink, Tarunveer S. Ahluwalia, Ping An, Emil V. Appel, Dan E Arking, Juha Auvinen, Lawrence F. Bielak, Nathan A. Bihlmeyer, Jette Bork-Jensen, Jennifer A. Brody, Archie Campbell, Audrey Y Chu, Gail Davies, Ayse Demirkan, James S. Floyd, Franco Giulianini, Xiuqing Guo, Stefan Gustafsson, Benoit Hastoy, Anne U. Jackson, Johanna Jakobsdottir, Marjo-Riitta Järvelin, Richard A. Jensen, Stavroula Kanoni, Sirkka Keinanen-Kiukaanniemi, Jin Li, Man Li, Kurt Lohman, Yingchang Lu, Jian’an Luan, Alisa K. Manning, Jonathan Marten, Carola Marzi, Karina Meidtner, Dennis O. Mook-Kanamori, Taulant Muka, Giorgio Pistis, Bram Prins, Kenneth M. Rice, Neil Robertson, Serena Sanna, Yuan Shi, Albert Vernon Smith, Jennifer A. Smith, Lorraine Southam, Heather M. Stringham, Salman M. Tajuddin, Vinicius Tragante, Sander W. van der Laan, Helen R. Warren, Jie Yao, Andrianos M. Yiorkas, Weihua Zhang, Wei Zhao, Emma Ahlqvist, Mariaelisa Graff, Heather M. Highland, Anne E. Justice, Ken Sin Lo, Eirini Marouli, Carolina Medina-Gomez, Saima Afaq, Wesam A. Alhejily, Najaf Amin, Folkert W. Asselbergs, Lori L. Bonnycastle, Michiel L. Bots, Ivan Brandslund, Ji Chen, Cramer Christensen, John Danesh, Renée de Mutsert, Abbas Dehghan, Tapani Ebeling, Paul Elliott, EPIC-InterAct Consortium, Aliki-Eleni Farmaki, Jessica D. Faul, Paul W. Franks, Steve Franks, Andreas Fritsche, Anette P. Gjesing, Mark O. Goodarzi, Vilmundur Gudnason, Göran Hallmans, Tamara B. Harris, Karl-Heinz Herzig, Marie-France Hivert, Jan-Håkan Jansson, Min A. Jhun, Torben Beck Jørgensen, Marit E. Jørgensen, Pekka Jousilahti, Eero Kajantie, Maria Karaleftheri, Sharon L.R. Kardia, Leena Kinnunen, Heikki A. Koistinena, Pirjo Komulainen, Peter Kovacs, Johanna Kuusisto, Markku Laakso, Leslie A. Lange, Lenore J. Launer, Jung-Jin Lee, Aaron Leong, Jaana Lindström, Jocelyn E. Manning Fox, Satu Männistö, Nisa M. Maruthur, Leena Moilanen, Antonella Mulas, Mike A. Nalls, Matthew Neville, James S. Pankow, Alison Pattie, Eva R. B. Petersen, Hannu Puolijoki, Asif Rasheed, Paul Redmond, Frida Renström, Michael Roden, Danish Saleheen, Juha Saltevo, Kai Savonen, Sylvain P. Sébert, Tea Skaaby, Kerrin S. Small, Alena Stančáková, Jakob Stokholm, Konstantin Strauch, E-Shyong Tai, Kent D. Taylor, Betina H. Thuesen, Anke Tönjes, Emmanouil Tsafantakis, Tiinamaija Tuomi, Jaakko Tuomilehto, Understanding Society Scientific Group, Matti I. Uusitupa, Marja Vääräsmäki, Ilonca Vaartjes, Magdalena Zoledziewska, Goncalo Abecasis, Beverley Balkau, Hans Bisgaard, Alexandra I. Blakemore, Matthias Blüher, Heiner Boeing, Eric Boerwinkle, Klaus Bønnelykke, Erwin P. Bottinger, Mark J. Caulfield, John C. Chambers, Daniel I. Chasman, Ching-Yu Cheng, Anne Clark, Francis S. Collins, Josef Coresh, Francesco Cucca, Gert J. de Borst, Ian J. Deary, George Dedoussis, Panos Deloukas, Hester M. den Ruijter, Josée Dupuis, Michele K. Evans, Ele Ferrannini, Oscar H. Franco, Harald Grallert, Leif Groop, Torben Hansen, Andrew T. Hattersley, Caroline Hayward, Joel N. Hirschhorn, M. Arfan Ikram, Erik Ingelsson, Fredrik Karpe, Kay-Tee Kaw, Wieland Kiess, Jaspal S. Kooner, Antje Körner, Timo Lakka, Claudia Langenberg, Lars Lind, Cecilia M. Lindgren, Allan Linneberg, Leonard Lipovich, Ching-Ti Liu, Jun Liu, Yongmei Liu, Ruth J. F. Loos, Patrick E. MacDonald, Karen L. Mohlke, Andrew D. Morris, Patricia B. Munroe, Alison Murray, Sandosh Padmanabhan, Colin N. A. Palmer, Gerard Pasterkamp, Oluf Pedersen, Patricia A. Peyser, Ozren Polasek, David Porteous, Michael A. Province, Bruce M. Psaty, Rainer Rauramaa, Paul M. Ridker, Olov Rolandsson, Patrik Rorsman, Frits Rosendaal, Igor Rudan, Veikko Salomaa, Matthias B. Schulze, Robert Sladek, Blair H. Smith, Timothy D. Spector, John M. Starr, Michael Stumvoll, Cornelia M. van Duijn, Mark Walker, Nick J. Wareham, David R. Weir, James G. Wilson, Tien Yin Wong, Eleftheria Zeggini, Alan B. Zonderman, Jerome I. Rotter, Andrew P. Morris, Michael Boehnke, Jose Florez, Mark I. McCarthy, James B. Meigs, Anubha Mahajan, Robert A. Scott, Anna L. Gloyn and Ines Barroso
University of Oxford, University of Cambridge, University of Oxford - Wellcome Centre for Human Genetics, Harvard University - Department of Genetics, Wellcome Trust Sanger Institute, Indiana University - Department of Epidemiology and Biostatistics, University of Oxford - Wellcome Centre for Human Genetics, Wellcome Trust Sanger Institute, University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism, National University of Singapore (NUS) - Saw Swee Hock School of Public Health, University of Exeter - Medical School, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford - Wellcome Centre for Human Genetics, Boston University - Department of Biostatistics, University of Michigan at Ann Arbor, Boston University - Department of Biostatistics, UCLA Medical Center, Leiden University - Medical Center (LUMC), University of Copenhagen - Novo Nordisk Foundation Center for Protein Research, Leiden University - Medical Center (LUMC), Lund University, Wellcome Genome Campus - Wellcome Trust Sanger Institute, University of Michigan at Ann Arbor - School of Public Health, University of Glasgow - College of Medical, Veterinary & Life Sciences, Wayne State University, University of Copenhagen - Herlev Hospital, Washington University in St. Louis - Department of Genetics, University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research, Johns Hopkins University - School of Medicine, University of Oulu, University of Michigan at Ann Arbor - Department of Epidemiology, Johns Hopkins University - School of Medicine, University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Washington, University of Edinburgh, Harvard University - Brigham and Women's Hospital, University of Edinburgh, Erasmus University Rotterdam (EUR) - Department of Epidemiology, University of Washington, Harvard University - Brigham and Women's Hospital, UCLA Medical Center, Uppsala University, University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Michigan at Ann Arbor, Icelandic Heart Association, University of Oulu, University of Washington, Queen Mary University of London - William Harvey Research Institute, University of Oulu - Centre for Life Course Health Research, Stanford University - Division of Cardiovascular Medicine, University of Utah, Wake Forest University, Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine, University of Cambridge - MRC Epidemiology Unit, Harvard University - Massachusetts General Hospital, University of Edinburgh - Medical Research Council Human Genetics Unit, Helmholtz Association of German Research Centres - Helmholtz Zentrum München, German Institute of Human Nutrition, Leiden University, Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC), Cittadella Universitaria, Wellcome Sanger Institute - Department of Human Genetics, University of Washington, University of Oxford - Wellcome Trust Centre for Human Genetics, Cittadella Universitaria, Singapore National Eye Centre - Singapore Eye Research Institute, Icelandic Heart Association, University of Michigan at Ann Arbor - Department of Epidemiology, Wellcome Sanger Institute - Department of Human Genetics, University of Michigan at Ann Arbor, National Institutes of Health - Laboratory of Epidemiology and Population Sciences, Utrecht University, University Medical Center (Utrecht), Queen Mary University of London - William Harvey Research Institute, UCLA Medical Center, Imperial College London, Imperial College London - Department of Epidemiology and Biostatistics, University of Michigan at Ann Arbor - Department of Epidemiology, Lund University - Diabetes Centre, University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology, University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology, University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology, University of Montreal - Université de Montreal, Queen Mary University of London - William Harvey Research Institute, Erasmus University Rotterdam (EUR) - Department of Epidemiology, Imperial College London - Department of Epidemiology and Biostatistics, Queen Mary University of London - William Harvey Research Institute, Erasmus University Rotterdam (EUR) - Department of Epidemiology, Utrecht University - University Medical Center (Utrecht), Government of the United States of America - National Institutes of Health (NIH), University Medical Center (Utrecht), Lillebaelt Hospital, Wellcome Sanger Institute - Department of Human Genetics, Lillebaelt Hospital, University of Cambridge - Department of Public Health and Primary Care, Leiden University, Erasmus University Rotterdam (EUR) - Department of Epidemiology, Oulu University Hospital, Imperial College London - Department of Epidemiology and Biostatistics, affiliation not provided to SSRN, Harokopio University, University of Michigan at Ann Arbor, Lund University - Department of Clinical Sciences, Imperial College London - Institute of Reproductive and Developmental Biology, University of Tuebingen - University Hospitals Tübingen, University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research, Cedars Sinai Medical Center, Icelandic Heart Association, University of Umea, Icelandic Heart Association, University of Oulu - Department of Physiology, Harvard Medical School, University of Umea - Department of Public Health and Clinical Medicine, University of Michigan at Ann Arbor - Department of Epidemiology, University of Copenhagen, Steno Diabetes Center Copenhagen, National Institute for Health and Welfare, University of Oulu, Echinos Medical Centre, University of Michigan at Ann Arbor - Department of Epidemiology, National Institute for Health and Welfare, National Institute for Health and Welfare, Kuopio Research Institute of Exercise Medicine, University of Leipzig - Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Eastern Finland, University of Eastern Finland, University of Colorado at Denver, National Institute for Health and Welfare, University of Pennsylvania, Harvard Medical School, National Institute for Health and Welfare, University of Alberta, National Institute for Health and Welfare, Johns Hopkins University, Kuopio University Hospital, Cittadella Universitaria, National Institutes of Health - Molecular Genetics Section, University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Minnesota - Minneapolis - Division of Epidemiology and Community Health, University of Edinburgh, Odense University Hospital, South Ostobothnia Central Hospital, Center for Non-Communicable Diseases, University of Edinburgh, Lund University - Department of Clinical Sciences, Heinrich Heine University Dusseldorf, University of Pennsylvania, Central Finland Central Hospital, Kuopio Research Institute of Exercise Medicine, University of Oulu - Centre for Life Course Health Research, Bispebjerg and Frederiksberg Hospitals, University of London - Department of Twin Research and Genetic Epidemiology, University of Eastern Finland, Herlev & Gentofte University Hospital - Copenhagen Prospective Study on Asthma in Childhood (COPSAC), Helmholtz Zentrum München Research Center for Environmental Health, National University of Singapore (NUS) - Department of Medicine, UCLA Medical Center, Bispebjerg and Frederiksberg Hospitals, University of Leipzig, Anogia Medical Centre, Folkhälsan Research Center, National Institute for Health and Welfare, affiliation not provided to SSRN, University of Eastern Finland, University of Oulu, University Medical Center (Utrecht), Cittadella Universitaria, University of Michigan at Ann Arbor, Centre de Recherche en Épidémiologie et Santé des Populations (CESP), Herlev & Gentofte University Hospital - Copenhagen Prospective Study on Asthma in Childhood (COPSAC), Brunel University London, University of Leipzig - Department of Medicine, German Institute of Human Nutrition - Department of Epidemiology, University of Texas at Houston, Herlev & Gentofte University Hospital - Copenhagen Prospective Study on Asthma in Childhood (COPSAC), Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine, Queen Mary University of London - William Harvey Research Institute, Imperial College London, Brigham and Women's Hospital, Singapore National Eye Centre - Singapore Eye Research Institute, University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism, National Institutes of Health (NIH), Johns Hopkins University, Italian National Research Council (CNR) - Istituto di Ricerca Genetica e Biomedica (IRGB), University Medical Center (Utrecht), University of Edinburgh - School of Philosophy, Psychology and Language Studies, Harokopio University, Queen Mary University of London - William Harvey Research Institute, University Medical Center (Utrecht), Boston University - Department of Biostatistics, National Institutes on Aging - Laboratory of Epidemiology and Population Sciences, University of Pisa, Erasmus University Rotterdam (EUR) - Department of Epidemiology, German Center for Diabetes Research, Lund University - Department of Clinical Sciences, University of Copenhagen - Faculty of Health and Medical Sciences, University of Exeter - Medical School, University of Edinburgh - MRC Human Genetics Unit, Harvard University - Department of Pediatrics, Erasmus University Rotterdam (EUR), Medical Center, Department of Epidemiology, Stanford University - Division of Cardiology, University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Cambridge - Department of Public Health and Primary Care, University of Leipzig - Center for Pediatric Research, Imperial College London, University of Leipzig, University of Eastern Finland - Institute of Biomedicine, University of Cambridge - MRC Epidemiology Unit, Uppsala University - Department of Medical Sciences, Masssachusetts Institute of Technology and Harvard University - Broad Institute, Bispebjerg and Frederiksberg Hospitals, Wayne State University, Boston University - Department of Biostatistics, Erasmus University Rotterdam (EUR) - Department of Epidemiology, Wake Forest University, Mount Sinai Health System - Charles Bronfman Institute for Personalized Medicine, University of Alberta, University of North Carolina (UNC) at Chapel Hill - Department of Genetics, University of Edinburgh - Usher Institute of Population Health Sciences and Informatics, Queen Mary University of London - William Harvey Research Institute, University of Aberdeen, University of Glasgow, University of Dundee - Division of Population Health and Genomics, University Medical Center (Utrecht), University of Copenhagen - Faculty of Health and Medical Sciences, University of Michigan at Ann Arbor - Department of Epidemiology, University of Split, University of Edinburgh, Washington University in St. Louis, University of Washington, Kuopio Research Institute of Exercise Medicine, Brigham and Women's Hospital, University of Umea, University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism, Leiden University - Medical Center (LUMC), University of Edinburgh - Usher Institute of Population Health Sciences and Informatics, National Institute for Health and Welfare, German Institute of Human Nutrition, McGill University - Department of Medicine, University of Dundee - Division of Population Health and Genomics, King's College London, Department of Twin Research and Genetic Epidemiology, University of Edinburgh, University of Leipzig, Erasmus University Rotterdam (EUR) - Department of Epidemiology, University of Newcastle - Institute of Cellular Medicine, University of Cambridge - MRC Epidemiology Unit, University of Michigan at Ann Arbor, University of Mississippi - Medical Center, Singapore National Eye Centre - Singapore Eye Research Institute, Wellcome Trust Sanger Institute, National Institutes on Aging - Laboratory of Epidemiology and Population Sciences, UCLA Medical Center, University of Liverpool - Department of Biostatistics, University of Michigan at Ann Arbor, Massachusetts General Hospital, University of Oxford - Wellcome Centre for Human Genetics, Massachusetts General Hospital, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Cambridge - MRC Epidemiology Unit, University of Oxford - Oxford Centre for Diabetes, Endocrinology and Metabolism and Wellcome Trust Sanger Institute
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genetics, Genomics, glycemic traits, type 2 diabetes, tissue, pathways, effector transcript

3.

Coding Variant In LEP Associated with Lower Leptin Concentrations Implicates Leptin in the Regulation of Early Adiposity

CELL-METABOLISM-D-19-01062
Number of pages: 452 Posted: 23 Oct 2019
Hanieh Yaghootkar, Yiying Zhang, Cassandra N. Spracklen, Tugce Karaderi, Lam Opal Huang, Jonathan Bradfield, Claudia Schurmann, Rebecca S. Fine, Michael H. Preuss, Zoltan Kutalik, Laura BL Wittemans, Yingchang Lu, Sophia Metz, Sara M. Willems, Ruifang Li-Gao, Niels Grarup, Shuai Wang, Sophie Molnos, América A. Sandoval-Zárate, Mike A. Nalls, Leslie A. Lange, Jeffrey Haesser, Xiuqing Guo, Leo-Pekka Lyytikäinen, Mary F. Feitosa, Colleen M. Sitlani, Cristina Venturini, Anubha Mahajan, Tim Kacprowski, Carol A. Wang, Daniel I. Chasman, Najaf Amin, Linda Broer, Neil Robertson, Kristin L. Young, Matthew Allison, Paul L. Auer, Matthias Blüher, Judith B. Borja, Jette Bork-Jensen, Germán D. Carrasquilla, Paraskevi Christofidou, Ayse Demirkan, Claudia A. Doege, Melissa E. Garcia, Mariaelisa Graff, Kaiying Guo, Hakon Hakonarson, Jaeyoung Hong, Yii-Der Ida Chen, Rebecca Jackson, Hermina Jakupović, Pekka Jousilahti, Anne E. Justice, Mika Kähönen, Jorge R. Kizer, Jennifer Kriebel, Charles A. LeDuc, Jin Li, Lars Lind, Jian’an Luan, David Mackey, Massimo Mangino, Satu Männistö, Jayne F. Martin Carli, Carolina Medina-Gomez, Dennis O. Mook-Kanamori, Andrew P. Morris, Renée de Mutsert, Matthias Nauck, Ivana Nedeljkovic, Craig E. Pennell, Arund D. Pradhan, Bruce M. Psaty, Olli T. Raitakari, Robert A. Scott, Tea Skaaby, Konstantin Strauch, Kent D. Taylor, Alexander Teumer, Andre G. Uitterlinden, Ying Wu, Jie Yao, Mark Walker, Kari E. North, Peter Kovacs, M. Arfan Ikram, Cornelia M. van Duijn, Paul M. Ridker, Stephen Lye, Georg Homuth, Erik Ingelsson, Timothy D. Spector, Barbara McKnight, Michael A. Province, Terho Lehtimäki, Linda Adair, Jerome I. Rotter, Alexander P. Reiner, James G. Wilson, Tamara Harris, Samuli Ripatti, Harald Grallert, James B. Meigs, Veikko Salomaa, Torben Hansen, Ko Willems van Dijk, Nicholas J. Wareham, Struan FA Grant, Claudia Langenberg, Timothy M. Frayling, Cecilia M. Lindgren, Karen L. Mohlke, Rudolph L. Leibel, Ruth JF Loos and Tuomas O. Kilpeläinen
University of Exeter - Genetics of Complex Traits, Columbia University, University of North Carolina (UNC) at Chapel Hill - Department of Genetics, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research, The Children's Hospital of Philadelphia - Center for Applied Genomics, Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine, Harvard University - Department of Genetics, Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine, University of Exeter - Genetics of Complex Traits, University of Oxford - Wellcome Trust Centre for Human Genetics, Icahn School of Medicine at Mount Sinai - Charles Bronfman Institute for Personalized Medicine, University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Cambridge, Leiden University - Medical Center (LUMC), University of Copenhagen - Novo Nordisk Foundation Center for Protein Research, Boston University - Department of Biostatistics, German Center for Diabetes Research, Institute for Molecular Medicine Finland (FIMM), National Institutes of Health - Molecular Genetics Section, University of Colorado at Denver, Fred Hutchinson Cancer Research Center - Public Health Sciences Division, UCLA Medical Center, Tampere University - Department of Clinical Chemistry, Washington University in St. Louis, University of Washington, University of London - Department of Twin Research and Genetic Epidemiology, University of Oxford - Wellcome Trust Centre for Human Genetics, University Medicine Greifswald, Boston University - Department of Biostatistics, Brigham and Women's Hospital, Erasmus University Rotterdam (EUR) - Department of Epidemiology, Erasmus University Rotterdam (EUR) - Department of Internal Medicine, University of Oxford - Wellcome Trust Centre for Human Genetics, University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology, University of California, San Diego (UCSD) - Department of Family Medicine and Public Health, University of Wisconsin - Milwaukee, University of Leipzig - Department of Medicine, University of San Carlos, University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research, University of London - Department of Twin Research and Genetic Epidemiology, Erasmus University Rotterdam (EUR) - Department of Epidemiology, Columbia University - Department of Pathology and Cell Biology, National Heart, Lung, and Blood Institute, University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology, Columbia University, The Children’s Hospital of Philadelphia - Center for Applied Genomics, Boston University - Department of Biostatistics, UCLA Medical Center, Ohio State University (OSU), University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research, National Institute for Health and Welfare, Center for Biomedical and Translational Informatics, Tampere University - Tampere University Hospital, University of California, San Diego (UCSD), German Center for Diabetes Research, Columbia University, Stanford University, Uppsala University - Department of Medical Sciences, University of Cambridge - MRC Epidemiology Unit, The University of Western Australia, University of London - Department of Twin Research and Genetic Epidemiology, National Institute for Health and Welfare, Columbia University, Erasmus University Rotterdam (EUR) - Department of Epidemiology, Leiden University, University of Liverpool - Department of Biostatistics, Leiden University, University of Greifswald - University Medicine Greifswald, Erasmus University Rotterdam (EUR) - Department of Epidemiology, Boston University - Department of Biostatistics, Brigham and Women's Hospital, University of Washington, Turku University Hospital, University of Cambridge - MRC Epidemiology Unit, Bispebjerg and Frederiksberg Hospitals, Helmholtz Zentrum München Research Center for Environmental Health, UCLA Medical Center, University of Greifswald - University Medicine Greifswald, Erasmus University Rotterdam (EUR), Medical Center, Department of Internal Medicine, University of North Carolina (UNC) at Chapel Hill - Department of Genetics, UCLA Medical Center, University of Newcastle - Institute of Cellular Medicine, University of North Carolina (UNC) at Chapel Hill - Department of Epidemiology, University of Leipzig - Integrated Research and Treatment Center (IFB) Adiposity Diseases, Erasmus University Rotterdam (EUR), Medical Center, Department of Epidemiology, Erasmus University Rotterdam (EUR) - Department of Epidemiology, Brigham and Women's Hospital, Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute, Research Centre for Women’s and Infants’ Health, University Medicine Greifswald, Stanford University - Division of Cardiology, King's College London, Department of Twin Research and Genetic Epidemiology, University of Washington - Department of Biostatistics, Washington University in St. Louis, University of Turku, Nutrition Epidemiology Division, UNC-CH, UCLA Medical Center, Fred Hutchinson Cancer Research Center - Public Health Sciences Division, University of Mississippi - Medical Center, Government of the United States of America - Laboratory of Epidemiology, Demography, and Biometry, Masssachusetts Institute of Technology and Harvard University - Broad Institute, German Center for Diabetes Research, Massachusetts General Hospital, National Institute for Health and Welfare, University of Copenhagen - Faculty of Health and Medical Sciences, Leiden University - Division of Endocrinology, University of Cambridge - Department of Public Health and Primary Care, The Children's Hospital of Philadelphia - Center for Applied Genomics, University of Cambridge - MRC Epidemiology Unit, University of Exeter - Genetics of Complex Traits, Masssachusetts Institute of Technology and Harvard University - Broad Institute, University of North Carolina (UNC) at Chapel Hill - Department of Genetics, Columbia University, Icahn School of Medicine at Mount Sinai - Mindich Child Health and Development Institute and University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research
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Abstract:

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Leptin, adiposity, exome-targeted array, GWAS, obesity