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Kazuo Tsubota

Keio University - Department of Ophthalmology

35 Shinanomachii

Tokyo, 160-8582

Japan

SCHOLARLY PAPERS

10

DOWNLOADS
Rank 49,600

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Top 49,600

in Total Papers Downloads

2,506

TOTAL CITATIONS

6

Scholarly Papers (10)

1.

Loss of Epigenetic Information as a Cause of Mammalian Aging

Number of pages: 102 Posted: 27 Oct 2021
Harvard University - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard University - Paul F. Glenn Center for Biology of Aging Research, Carnegie Mellon University - Computational Biology Department, Dovetail Genomics, Dovetail Genomics, Dovetail Genomics, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard University - Paul F. Glenn Center for Biology of Aging Research, Harvard University - Paul F. Glenn Center for Biology of Aging Research, Harvard University - Paul F. Glenn Center for Biology of Aging Research, Harvard University - Paul F. Glenn Center for Biology of Aging Research, Zymo Research Corporation, Zymo Research Corporation, Zymo Research Corporation, Harvard Medical School - Genetics Division, Harvard University - Paul F. Glenn Center for Biology of Aging Research, University of Pennsylvania - Department of Cell and Developmental Biology, University of Pennsylvania - Department of Cell and Developmental Biology, University of Washington - Division of Nephrology, University of Washington - Division of Nephrology, National Institutes of Health - Experimental Gerontology Section, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, University of California, Santa Cruz - Department of Biomolecular Engineering (BME), Harvard University - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Carnegie Mellon University - Computational Biology Department, Tokyo Medical and Dental University - Department of Stem Cell Biology, Tokyo Medical and Dental University - Department of Stem Cell Biology, Vium Inc., Harvard University - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Schepens Eye Research Institute, Harvard Medical School - Schepens Eye Research Institute, Harvard Medical School - The Massachusetts General Hospital Cancer Center, Harvard Medical School - Department of Genetics, Harvard Medical School - Cancer Center, Harvard University - Department of Stem Cell and Regenerative Biology, Keio University - Department of Ophthalmology, University of Nebraska Medical Center - Division of Geriatrics, Gerontology, and Palliative Medicine, Universidade de Coimbra - Department of Life Sciences, Harvard Medical School - Department of Genetics, Harvard Medical School - Department of Genetics, University of Washington - Department of Pathology, Brown University - Department of Molecular Biology, Cell Biology and Biochemistry, Brown University - Department of Molecular Biology, Cell Biology and Biochemistry, Harvard University - Program in Dermatopathology, University of California, Santa Cruz - Department of Biomolecular Engineering (BME), University of Pennsylvania - Department of Cell and Developmental Biology, University of Pennsylvania - Department of Cell and Developmental Biology, National Institutes of Health - Laboratory of Receptor Biology and Gene Expression, University of Washington - Division of Nephrology, Harvard Medical School - Genetics Division, Harvard Medical School - Schepens Eye Research Institute, Carnegie Mellon University - Department of Computational Biology, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research and Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research
Downloads 1,262 (40,523)
Citation 1

Abstract:

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DNA damage, Chromatin, aging, epigenetic clock, epigenetic reprogramming, senescence, RCM (Relocalization of Chromatin Modifiers)

2.

DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

Number of pages: 97 Posted: 08 Oct 2019
Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Zymo Research Corporation, Zymo Research Corporation, Zymo Research Corporation, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, National Institutes of Health - Experimental Gerontology Section, Tokyo Medical and Dental University - Department of Stem Cell Biology, Tokyo Medical and Dental University - Department of Stem Cell Biology, Vium Inc., Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Schepens Eye Research Institute, Harvard Medical School - Schepens Eye Research Institute, Harvard Medical School - Cancer Center, Harvard University - Harvard Medical School, Harvard Medical School - Cancer Center, Harvard University - Department of Stem Cell and Regenerative Biology, Keio University - Department of Ophthalmology, University of Nebraska Medical Center - Division of Geriatrics, Gerontology, and Palliative Medicine, Universidade de Coimbra - Department of Life Sciences, Harvard Medical School - Department of Genetics, Harvard Medical School - Department of Genetics, University of Washington - Department of Pathology, Brown University - Department of Molecular Biology, Cell Biology and Biochemistry, Brown University - Department of Molecular Biology, Cell Biology and Biochemistry, Harvard Medical School - Program in Dermatopathology, National Institutes of Health - Laboratory of Receptor Biology and Gene Expression, Harvard Medical School - Schepens Eye Research Institute, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research and Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research
Downloads 349 (214,990)
Citation 2

Abstract:

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DNA damage, chromatin, aging, epigenetic clock, histone modification, RCM(Relocalization of Chromatin Modifiers)

3.

Artificial Intelligence-Based Cataract Diagnosis Using Video Recording and Machine Learning: A Retrospective Study

Number of pages: 29 Posted: 19 Oct 2020
Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, OUI, Inc, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Preventive Medicine and Public Health, Keio University - Department of Preventive Medicine and Public Health and Keio University - Department of Ophthalmology
Downloads 196 (387,924)
Citation 3

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Artificial Intelligence, cataract, machine learning, smart eye camera, diagnosis

4.

Artificial Intelligence to Estimate the Tear Film Breakup Time and Diagnose Dry Eye Disease

Number of pages: 20 Posted: 22 Nov 2022
Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, OUI, Inc, Keio University - Department of Ophthalmology, OUI, Inc, OUI, Inc, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Preventive Medicine and Public Health, Keio University - Department of Ophthalmology and Keio University - Department of Ophthalmology
Downloads 138 (530,816)

Abstract:

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Dry eye disease, innovation, mobile device, Smart eye camera, telemedicine, tear film break-up time

5.

Comprehensive Analysis of Long COVID in a Japanese Nationwide Prospective Cohort Study

Number of pages: 31 Posted: 21 Nov 2022
Hideki Terai, Makoto Ishii, Ryo Takemura, Ho Namkoong, Kyoko Shimamoto, Katsunori Masaki, Takae Tanosaki, Shotaro Chubachi, Emiko Matsuyama, Reina Hayashi, Takashi Shimada, Lisa Shigematsu, Fumimaro Ito, Masanori Kaji, Hatsuyo Takaoka, Momoko Kurihara, Kensuke Nakagawara, Saki Tomiyasu, Kotaro Sasahara, Ayaka Saito, Shiro Otake, Shuhei Azegawa, Masahiko Okada, Takahiro Fukushima, Atsuho Morita, Hiromu Tanaka, Keeya Sunata, Masato Asaoka, Miyuki Nishie, Taro Shinozaki, Toshiki Ebisudani, Yuto Akiyama, Akifumi Mitsuishi, Shingo Nakayama, Takunori Ogawa, Kaori Sakurai, Misato Kuwae, Kazuma Yagi, Keiko Ohgino, Jun Miyata, Hiroki Kabata, Shinnosuke Ikemura, Hirofumi Kamata, Hiroyuki Yasuda, Ichiro Kawada, Ryusei Kimura, Masahiro Kondo, Toshiki Iwasaki, Noriyuki Ishida, Gaku Hiruma, Naoki Miyazaki, Yoshiki Ishibashi, Sei Harada, Takanori Fujita, Daisuke Ito, Shogyoku Bun, Hajime Tabuchi, Sho Kanzaki, Eisuke Shimizu, Keitaro Fukuda, Jun Yamagami, Keigo Kobayashi, Toshiyuki Hirano, Takashi Inoue, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Ho Lee, Kai Sugihara, Nao Omori, Koichi Sayama, Kengo Otsuka, Naoki Miyao, Toshio Odani, Takao Mochimaru, Ryosuke Satomi, Yoshitaka Oyamada, Keita Masuzawa, Takanori Asakura, Mayuko Watase, Sohei Nakayama, Yusuke Suzuki, Rie Baba, Satoshi Okamori, Daisuke Arai, Ichiro Nakachi, Naota Kuwahara, Akiko Fujiwara, Takenori Okada, Takashi Ishiguro, Taisuke Isono, Yasushi Makino, Shuko Mashimo, Tatsuya Kaido, Naoto Minematsu, Soichiro Ueda, Kazuhiro Minami, Rie Hagiwara, Tadashi Manabe, Takahiro Fukui, Yohei Funatsu, Hidefumi Koh, Takashi Yoshiyama, Hiroyuki Kokuto, Tatsuya Kusumoto, Ayano Oashi, Masayoshi Miyawaki, Fumitake Saito, Tetsuo Tani, Kota Ishioka, Saeko Takahashi, Morio Nakamura, Norihiro Harada, Hitoshi Sasano, Ai Nakamura, Yu Kusaka, Takehiko Ohba, Yasushi Nakano, Kazumi Nishio, Yukiko Nakajima, Shoji Suzuki, Shuichi Yoshida, Hiroki Tateno, Nobuhiro Kodama, Shunsuke Maeda, Satoshi Sakamoto, Masaki Okamoto, Yoji Nagasaki, Akira Umeda, Kasuya Miyagawa, Naoto Shimada, Kazuto Hagimura, Kengo Nagashima, Toshiro Sato, Yasunori Sato, Naoki Hasegawa, Toru Takebayashi, Jin Nakahara, Masaru Mimura, Kaoru Ogawa, Shigeto Shimmura, Kazuno Negishi, Kazuo Tsubota, Masayuki Amagai, Rei Goto, Yoko Ibuka, Yuko Kitagawa, Takanori Kanai and Koichi Fukunaga
Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University Hospital Clinical and Translational Research Center, Keio University - Division of Pulmonary Medicine, Keio University - Keio Global Research Institute, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Hino Municipal Hospital - Department of Internal Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Keio University Hospital Clinical and Translational Research Center, Keio University Hospital Clinical and Translational Research Center, Keio University Hospital Clinical and Translational Research Center, Keio University Hospital Clinical and Translational Research Center, Keio University Hospital Clinical and Translational Research Center, Keio University Hospital Clinical and Translational Research Center, Keio University - Department of Preventive Medicine and Public Health, Keio University - Department of Preventive Medicine and Public Health, Keio University - Department of Health Policy and Management, Keio University - School of Medicine, Keio University - Department of Neuropsychiatry, Keio University - Department of Neuropsychiatry, Keio University - Department of Otorhinolaryngology, Head and Neck Surgery, Keio University - Department of Ophthalmology, Keio University - Department of Dermatology, Keio University - Department of Dermatology, Sano Kosei General Hospital, Sano Kosei General Hospital, Sano Kosei General Hospital, Keiyu Hospital, Keiyu Hospital, Keiyu Hospital, Keio University - Division of Pulmonary Medicine, Kawasaki Municipal Hospital, Kawasaki Municipal Hospital, Kawasaki Municipal Hospital, Nihon Koukan Hospital - Department of Internal Medicine, Nihon University - Department of Internal Medicine, National Hospital Organization Hokkaido Medical Center - Department of Rheumatology, National Hospital Organisation Tokyo Medical Center - Department of Respiratory Medicine, National Hospital Organisation Tokyo Medical Center - Department of Respiratory Medicine, National Hospital Organisation Tokyo Medical Center - Department of Respiratory Medicine, Kitasato University - Department of Respiratory Medicine, Keio University - Department of Health Policy and Management, Keio University - Division of Pulmonary Medicine, Kitasato University - Department of Respiratory Medicine, Kitasato University - Department of Respiratory Medicine, Saiseikai Utsunomiya Hospital, Keio University - Division of Pulmonary Medicine, Saiseikai Utsunomiya Hospital, Saiseikai Utsunomiya Hospital, Showa University - Division of Allergology and Respiratory Medicine, Showa University - Division of Allergology and Respiratory Medicine, Showa University - Division of Allergology and Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama Cardiovascular and Respiratory Center, Toyohashi Municipal Hospital, Toyohashi Municipal Hospital, Toyohashi Municipal Hospital, Hino Municipal Hospital, Saitama City Hospital - Department of Internal Medicine, Saitama University - Saitama Medical Center, Saitama University - Saitama Medical Center, Keio University - Division of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Tachikawa Hospital - Division of Pulmonary Medicine, Tachikawa Hospital - Division of Pulmonary Medicine, Japan Anti-Tuberculosis Association - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Keio University - Division of Pulmonary Medicine, Eiju General Hospital - Department of Pulmonary Medicine, Eiju General Hospital - Department of Pulmonary Medicine, Eiju General Hospital - Department of Pulmonary Medicine, Keio University - Division of Pulmonary Medicine, Kawasaki Municipal Ida Hospital, Kawasaki Municipal Ida Hospital, Kawasaki Municipal Ida Hospital, Juntendo University - Department of Respiratory Medicine, Kawasaki Municipal Ida Hospital, Kawasaki Municipal Ida Hospital, Kawasaki Municipal Ida Hospital, Kawasaki Municipal Ida Hospital, Kawasaki Municipal Ida Hospital - Department of Internal Medicine, Kawasaki Municipal Ida Hospital, Kawasaki Municipal Ida Hospital - Department of Pulmonary Medicine, Saitama City Hospital - Department of Pulmonary Medicine, Saitama City Hospital - Department of Pulmonary Medicine, Saitama City Hospital - Department of Pulmonary Medicine, Fukuoka Tokushukai Hospital - Department of General Internal Medicine, Fukuoka Tokushukai Hospital - Department of General Internal Medicine, Kurume University - Department of Internal Medicine, Kurume University - Department of Internal Medicine, Kyushu Medical Center - Division of Infectious Diseases, International University of Health and Welfare, Tochigi - Department of General Medicine, International University of Health and Welfare, Tochigi - School of Pharmacy, International University of Health and Welfare, Tochigi - Department of Respiratory Medicine, Keio University Hospital Clinical and Translational Research Center, Biostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Keio University - Department of Organoid Medicine, Keio University - Department of Preventive Medicine and Public Health, Keio University, School of Medicine, Center for Infectious Diseases and Infection Control, Keio University - Department of Preventive Medicine and Public Health, Department of Neurology, Keio University School of Medicine, Keio University - Department of Neuropsychiatry, Keio University - Department of Otorhinolaryngology, Head and Neck Surgery, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Dermatology, Keio University - Graduate School of Business Administration, Keio University - Faculty of Economics, Keio University - Department of Surgery, Keio University - Division of Gastroenterology and Hepatology and Keio University - Division of Pulmonary Medicine
Downloads 121 (592,433)

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Post COVID-19 conditions, general fatigue, patient reported outcome

6.

Dietary Supplement Crocetin Has a Suppressive Effect Against Myopia Progression: A Randomized Clinical Trial

Number of pages: 41 Posted: 23 May 2019
Keio University - School of Medicine, Keio University - School of Medicine, The University of Osaka - Graduate School of Medicine, Keio University - School of Medicine, Keio University - School of Medicine, Keio University - School of Medicine, The University of Osaka - Graduate School of Medicine, Keio University - Laboratory of Photobiology, The University of Osaka - Department of Ophthalmology and Keio University - Department of Ophthalmology
Downloads 120 (596,393)

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crocetin; supplement; myopia; axial length; refraction; myopia progression control; ,randomized double-blind placebo-controlled trial

7.

Assessment of the Functionality of a Smartphone-Attached Slit-Lamp Microscope and Fundoscopy Device (Smart Eye Camera): A Prospective Study

Number of pages: 32 Posted: 16 Jul 2025
Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Preventive Medicine and Public Health, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - School of Medicine, Keio University Hospital Clinical and Translational Research Center, Biostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, OUI, Inc, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Tsurumi University, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University - Department of Preventive Medicine and Public Health and Keio University - Department of Ophthalmology
Downloads 107 (654,668)

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Smartphone imaging, slit-lamp microscopy, fundus camera, tele-ophthalmology, diagnostic accuracy

8.

Single-Cell RNA-Sequencing Reveals the Transcriptional Landscape of Lacrimal Gland In GVHD Mouse Model

Number of pages: 33 Posted: 04 Dec 2023
Zhejiang University, Zhejiang University, Zhejiang University - Eye Centre, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Zhejiang University and Zhejiang University - Eye Centre
Downloads 98 (704,534)

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Single-Cell RNA-Sequencing, GVHD, Dry eye, Lacrimal gland

9.

Intraocular Vasculature Formation Precedes Extraocular Vasculature Penetration of Mouse Eyes

Number of pages: 25 Posted: 18 May 2025
Keio University, affiliation not provided to SSRN, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology and Keio University
Downloads 65 (916,100)

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ocular circulation, choriocapillaris, choroid, hyaloid, posterior ciliary artery

10.

The Choroidal Macrophage Polarization Significantly Influences Myopia Development in Murine Models

Number of pages: 37 Posted: 08 Sep 2025
Keio University, Keio University, Keio University, Keio University, Keio University, Keio University, Keio University, Keio University, Keio University, Keio University, Keio University - Department of Ophthalmology, Keio University - Department of Ophthalmology, Keio University and Independent
Downloads 50 (1,063,489)

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