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Ondrej Soukup

University Hospital Hradec Kralove

SCHOLARLY PAPERS

10

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Scholarly Papers (10)

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1.

Inhibition of Amyloid Fibrillization of Amyloid Β Peptide by 4,7-Disubstituted Coumarin Derivatives

Number of pages: 24 Posted: 08 May 2025
Slavka Hamulakova, Adrián Gucký, Roman Mezencev, Mária Kožurková, Zuzana Bednarikova, Jozef Marek, Ondrej Soukup, Jiri Janousek and Zuzana Gazova
affiliation not provided to SSRN, affiliation not provided to SSRN, Georgia Institute of Technology, affiliation not provided to SSRN, Slovak Academy of Sciences, affiliation not provided to SSRN, University Hospital Hradec Kralove, University Hospital Hradec Kralove and Slovak Academy of Sciences
Downloads 92 (742,061)

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Coumarin derivatives, Alzheimer´s disease, Antioxidant activity, Aβ peptide, amyloid aggregation, cell viability assay

2.

Privileged Multi-Target Directed Propargyl-Tacrines Combining Cholinesterase and Monoamine Oxidase Inhibition Activities

Number of pages: 37 Posted: 14 Mar 2022
Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova, Lubica Muckova, Lenka Nemcikova, Ondrej Soukup, Patrik Oleksak, Martin Valis, Jan Korabecny, José Marco-Contelles and Kamil Kuca
affiliation not provided to SSRN, affiliation not provided to SSRN, University of Hradec Králové, affiliation not provided to SSRN, affiliation not provided to SSRN, University Hospital Hradec Kralove, affiliation not provided to SSRN, University Hospital Hradec Kralove, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and affiliation not provided to SSRN
Downloads 67 (899,324)

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Cholinesterase inhibitor, Alzheimer's disease, Monoamine oxidase inhibitor, Propargyl amines, Tacrine

3.

Highly Selective Butyrylcholinesterase Inhibitors Related to Amaryllidaceae Alkaloids - Design, Synthesis, and Biological Evaluation

Number of pages: 62 Posted: 03 Mar 2023
Filip Pidany, Jana Kroustkova, Abdullah Al Mamun, Daniela Suchankova, Xavier Brazzolotto, Florian Nachon, Fabien Chantegreil, Rafael Dolezal, Lenka Pulkrabkova, Lubica Muckova, Martina Hrabinova, Vladimir Finger, Martin Kufa, Ondrej Soukup, Daniel Jun, Jaroslav Jenco, Jiri Kunes, Lucie Novakova, Jan Korabecny and Lucie Cahlikova
Charles University, Charles University, Charles University, Charles University, Place Général Valérie André, Place Général Valérie André, Place Général Valérie André, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University of Defence, Trebesska - Faculty of Military Health Sciences, Charles University, Charles University, Charles University, University Hospital Hradec Kralove and Charles University
Downloads 60 (961,006)

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Alzheimer's disease, Amaryllidaceae alkaloids, butyrylcholinesterase, cholinesterase inhibitors, crystallographic study, qsar

4.

Novel Antitubercular Agents Based on 2,4-Disubstituted 5-(Aryl-2-Ylmethyl)-5h-Pyrrolo[3,2-D]Pyrimidines

Number of pages: 74 Posted: 19 Jun 2025
Vladimir Finger, Martin Vrbicky, Lubica Muckova, Lukas Prchal, Martin Novák, Jan Marek, Ondrej Soukup, Michaela Hympanova, Ales Sorf, Marketa Benkova, Jan Bartacek, Pavel Drabina, Martin Kufa, Ondrej Kovar, Lenka Fikejzlová, Martin Hruby, Oksana Ozhelevska, Johannes Jagob, Jana Zdarova Karasova, Jitka Odvarkova, Iveta Kaderavková, Tomas Rozsypal, Katarzyna Ewa Greber, Krzesimir Ciura, Jiri Janousek, Martin Kratky, Ivone C. Igreja Sa, Pavel Bostik, Radek Sleha, Jaroslav Roh and Jan Korabecny
affiliation not provided to SSRN, University of Pardubice, University Hospital Hradec Kralove, University Hospital Hradec Kralove, Charles University, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove, affiliation not provided to SSRN, University Hospital Hradec Kralove, University of Pardubice, University of Pardubice, University Hospital Hradec Kralove, affiliation not provided to SSRN, affiliation not provided to SSRN, Academy of Sciences of the Czech Republic, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Medical University of Gdansk, Medical University of Gdansk, University Hospital Hradec Kralove, Charles University, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and University Hospital Hradec Kralove
Downloads 57 (989,921)

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deazapurine, Mycobacterium tuberculosis, pyrrole, pyrimidine, tuberculosis

5.

Phenoxytacrine Derivatives: Low-Toxicity Neuroprotectants Exerting Affinity to Ifenprodil-Binding Site and Cholinesterase Inhibition

Number of pages: 49 Posted: 19 Dec 2023
Anna Misiachna, Barbora Svobodova, Jakub Netolicky, Marketa Chvojkova, Lenka Kleteckova, Lukas Prchal, Martin Novák, Martina Hrabinova, Tomas Kucera, Lubica Muckova, Zuzana Moravcova, Jana Zdarova Karasova, Jaroslav Pejchal, Kristina Hakenova, Barbora Hrcka Krausova, Marharyta Kolcheva, Marek Ladislav, Jan Korabecny, Jens Pahnke, Karel Vales, Martin Horak and Ondrej Soukup
Czech Academy of Sciences, University Hospital Hradec Kralove, Institute of Experimental Medicine of the CAS, National Institute of Mental Health, Czech Republic, National Institute of Mental Health, Czech Republic, University Hospital Hradec Kralove, Charles University, University Hospital Hradec Kralove, University of Defence in Brno, University Hospital Hradec Kralove, Charles University, University Hospital Hradec Kralove, University Hospital Hradec Kralove, National Institute of Mental Health, Czech Republic, Institute of Experimental Medicine of the CAS, Institute of Experimental Medicine of the CAS, Institute of Experimental Medicine of the CAS, University Hospital Hradec Kralove, University of Oslo, Government of the United States of America - National Institute of Mental Health, Czech Academy of Sciences and University Hospital Hradec Kralove
Downloads 53 (1,031,043)

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Alzheimer´s disease; electrophysiology; glutamate receptor; acetylcholinesterase; neuroprotection; in vivo; Tacrine

6.

Carltonine-Derived Compounds for Targeted Butyrylcholinesterase Inhibition

Number of pages: 43 Posted: 28 Nov 2023
Filip Pidany, Jana Kroustkova, Jaroslav Jenco, Katerina Hradiska Breiterova, Lubica Muckova, Lucie Novakova, Jiri Kunes, Jakub Fibigar, Tomas Kucera, Ales Sorf, Martina Hrabinova, Lenka Pulkrabkova, Ondrej Soukup, Daniel Jun, Jan Korabecny and Lucie Cahlikova
Charles University, Charles University, Charles University, Charles University, University Hospital Hradec Kralove, Charles University, Charles University, affiliation not provided to SSRN, University of Defence in Brno, University of Defense, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University of Defence, Trebesska - Faculty of Military Health Sciences, University Hospital Hradec Kralove and Charles University
Downloads 46 (1,109,210)

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Alzheimer's disease, Amaryllidaceae alkaloids, acetylcholinesterase, butyrylcholinesterase, cholinesterase inhibitors

7.

2,6-Disubstituted 7-(Naphthalen-2-Ylmethyl)-7h-Purines as a New Class of Potent Antitubercular Agents Inhibiting Dpre1

Number of pages: 85 Posted: 18 May 2023
Vladimir Finger, Tomas Kucera, Radka Kafkova, Lubica Muckova, Rafael Dolezal, Jan Kubes, Martin Novák, Lukas Prchal, Levente Lakatos, Martin Andrs, Michaela Hympanova, Jan Marek, Martin Kufa, Vojtech Spiwok, Ondrej Soukup, Eva Mezeiova, Jiri Janousek, Lenka Nevosadova, Marketa Benkova, Russell Kitson, Martin Kratky, Szilvia Bősze, Katarína Mikušová, Ruben Hartkoorn, Jaroslav Roh and Jan Korabecny
University Hospital Hradec Kralove, University of Defence in Brno, Comenius University, University Hospital Hradec Kralove, University Hospital Hradec Kralove, Charles University, Charles University, University Hospital Hradec Kralove, Eötvös Loránd University, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University of Chemistry and Technology, Prague, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove, Charles University, University Hospital Hradec Kralove, Charles University, Charles University, Eötvös Loránd University, Comenius University, University of Lille - CHU Lille, Charles University and University Hospital Hradec Kralove
Downloads 36 (1,249,711)

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Tuberculosis, purine, Mycobacterium tuberculosis, DprE1, Structure-activity relationships

8.

Ph-Induced Morphological Reversible Transition from Microparticles to Vesicles for Effective Bacteria Entrapment

Number of pages: 22 Posted: 27 Aug 2024
Vladimir Sincari, Svetlana Lukáš Petrova, Eliézer Jäger, Alessandro Jäger, Rafał Konefał, Veronika Gajdošová, Miroslav Slouf, Michaela Hympanova, Jan Marek, Ondrej Soukup and Martin Hruby
Czech Academy of Sciences, Academy of Sciences of the Czech Republic, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Czech Academy of Sciences, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove and Academy of Sciences of the Czech Republic
Downloads 33 (1,277,121)

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microparticles, pH-responsive, bacteria, microfluidics, vesicles, polymersomes

9.

Ph-Induce Morphological Reversible Transition from Microparticles to Vesicles for Effective Bacteria Entrapment

Number of pages: 18 Posted: 26 Apr 2024
Vladimir Sincari, Svetlana Lukáš Petrova, Eliézer Jäger, Alessandro Jäger, Veronika Gajdošová, Miroslav Slouf, Michaela Hympanova, Jan Marek, Ondrej Soukup and Martin Hruby
Czech Academy of Sciences, Academy of Sciences of the Czech Republic, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Czech Academy of Sciences, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University Hospital Hradec Kralove and Academy of Sciences of the Czech Republic
Downloads 31 (1,318,317)

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microparticles, pH-responsive, bacteria, microfluidics, vesicles, polymersomes

10.

Carltonine B Derivatives: Synthesis and Structure-Activity Relationship Insights for Selective Butyrylcholinesterase Inhibition

Number of pages: 53 Posted: 19 Feb 2026
Abdullah Al Mamun, Jan Konecny, Martina Hrabinova, Ales Sorf, Lubica Muckova, Lenka Pulkrabkova, Daniel Jun, Lukas Prchal, Dawid Panek, Vladimir Finger, Ondrej Soukup, Thomas Cailly, Valérie Collot, Lucie Nováková, Lucie Cahlikova and Jan Korabecny
affiliation not provided to SSRN, affiliation not provided to SSRN, University Hospital Hradec Kralove, University of Defense, University Hospital Hradec Kralove, University Hospital Hradec Kralove, University of Defence, Trebesska - Faculty of Military Health Sciences, University Hospital Hradec Kralove, Jagiellonian University in Krakow - Faculty of Pharmacy, affiliation not provided to SSRN, University Hospital Hradec Kralove, University of Caen Normandy, affiliation not provided to SSRN, affiliation not provided to SSRN, Charles University and University Hospital Hradec Kralove
Downloads 25 (1,411,822)

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Amaryllidaceae alkaloid, Alzheimer's Disease, butyrylcholinesterase, Enzyme inhibition, cytotoxicity